Injectable and implantable cellular-scale electronic devices

Rogers, John A.; Bruchas, Michael Raymond; Gereau, Robert; McCall, Jordan Gary; Brenner, Daniel; Kim, Tae il; Shin, Gunchul; Jeong, Jae-Yong

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Title: Injectable and implantable cellular-scale electronic devices

Abstract

Provided are implantable or surface mounted biomedical devices and related methods for interfacing with a target tissue. The devices have a substrate and device component supported by the substrate. The components of the device are specially configured and packaged to be ultra-thin and mechanically compliant. In particular, device thicknesses are less than 1 mm and have lateral dimensions between about 1 m and 10 mm, depending on the application. Delivery substrates may be incorporated to assist with device implantation and handling. The devices can be shaped to provide injection in a minimally invasive manner, thereby avoiding unnecessary tissue damage and providing a platform for long-term implantation for interfacing with biological tissue.

Inventors:: Rogers, John A.; Bruchas, Michael Raymond; Gereau, Robert; McCall, Jordan Gary; Brenner, Daniel; Kim, Tae il; Shin, Gunchul; Jeong, Jae-Yong

Issue Date:: Tue Apr 14 00:00:00 EDT 2020

Research Org.:: Univ. of Illinois at Urbana-Champaign, IL (United States); Washington Univ., St. Louis, MO (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1650753

Patent Number(s):: 10617300

Application Number:: 14/766,926

Assignee:: The Board of Trustees of the University of Illinois (Urbana, IL); Washington University (St. Louis, MO)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B2017/00004 - {
A61B2562/0285 - Nanoscale sensors
A61B2562/06 - Arrangements of multiple sensors of different types
A61B2562/12 - Manufacturing methods specially adapted for producing sensors for in-vivo measurements
A61B5/0031 - {Implanted circuitry}
A61B5/685 - {Microneedles}
A61B5/686 - {Permanently implanted devices, e.g. pacemakers, other stimulators, biochips

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61M - DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
A61M2037/0007 - {having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents}
A61M2037/0053 - {Methods for producing microneedles}
A61M2037/0061 - {Methods for using microneedles}
A61M2205/04 - implanted
A61M2205/05 - combined with other kinds of therapy
A61M2205/054 - with electrotherapy

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
A61N1/05 - for implantation or insertion into the body, e.g. heart electrode
A61N2005/0612 - {using probes penetrating tissue
A61N5/062 - {Photodynamic therapy, i.e. excitation of an agent}

Show less

DOE Contract Number:: FG02-07ER46453; FG02-07ER46471

Resource Type:: Patent

Resource Relation:: Patent File Date: 02/11/2014

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 36 MATERIALS SCIENCE

Citation Formats


                    Rogers, John A., Bruchas, Michael Raymond, Gereau, Robert, McCall, Jordan Gary, Brenner, Daniel, Kim, Tae il, Shin, Gunchul, and Jeong, Jae-Yong. Injectable and implantable cellular-scale electronic devices.  United States: N. p., 2020. 
        Web.

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                    Rogers, John A., Bruchas, Michael Raymond, Gereau, Robert, McCall, Jordan Gary, Brenner, Daniel, Kim, Tae il, Shin, Gunchul, & Jeong, Jae-Yong. Injectable and implantable cellular-scale electronic devices.  United States.

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                    Rogers, John A., Bruchas, Michael Raymond, Gereau, Robert, McCall, Jordan Gary, Brenner, Daniel, Kim, Tae il, Shin, Gunchul, and Jeong, Jae-Yong. Tue .  
        "Injectable and implantable cellular-scale electronic devices".  United States.  https://www.osti.gov/servlets/purl/1650753.

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@article{osti_1650753,

  title        = {Injectable and implantable cellular-scale electronic devices},

  author       = {Rogers, John A. and Bruchas, Michael Raymond and Gereau, Robert and McCall, Jordan Gary and Brenner, Daniel and Kim, Tae il and Shin, Gunchul and Jeong, Jae-Yong},

  abstractNote = {Provided are implantable or surface mounted biomedical devices and related methods for interfacing with a target tissue. The devices have a substrate and device component supported by the substrate. The components of the device are specially configured and packaged to be ultra-thin and mechanically compliant. In particular, device thicknesses are less than 1 mm and have lateral dimensions between about 1 m and 10 mm, depending on the application. Delivery substrates may be incorporated to assist with device implantation and handling. The devices can be shaped to provide injection in a minimally invasive manner, thereby avoiding unnecessary tissue damage and providing a platform for long-term implantation for interfacing with biological tissue.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Apr 14 00:00:00 EDT 2020},

  month        = {Tue Apr 14 00:00:00 EDT 2020}

}

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US Patent Document 8,946,683
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8946683

Conformable Actively Multiplexed High-Density Surface Electrode Array for Brain Interfacing
patent-application, March 2015

Rogers, John; Kim, Dae-Hyeong; Litt, Brian
US Patent Application 14/532687; 20150080695
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20150080695

Transient devices designed to undergo programmable transformations
patent-application, June 2013

Rogers, John; Omenetto, Fiorenzo; Hwang, Suk-Won
US Patent Application 13/624096; 20130140649
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20130140649

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Title: Injectable and implantable cellular-scale electronic devices

Abstract

Citation Formats

High Resolution Electrohydrodynamic Jet Printing for Manufacturing Systems patent-application, October 2015

Printing-Based Assembly of Multi-Junction, Multi-Terminal Photovoltaic Devices and Related Methods patent-application, July 2015

Medical implant systems patent-application, December 2004

Pattern transfer printing by kinetic control of adhesion to an elastomeric stamp patent, May 2011

Implantable medical device controlled by a non-invasive physiological data measurement device patent-application, November 2001

Methods of making spatially aligned nanotubes and nanotube arrays patent, February 2013

Devices and methods for pattern generation by ink lithography patent-application, March 2008

Multispectral plasmonic crystal sensors patent, April 2010

Arrays of ultrathin silicon solar microcells patent, August 2015

Implantable Biomedical Devices on Bioresorbable Substrates patent-application, June 2014

Printed assemblies of ultrathin, microscale inorganic light emitting diodes for deformable and semitransparent displays patent, October 2014

Stretchable Electronic Systems With Fluid Containment patent-application, August 2014

Organ Mounted Electronics patent-application, May 2015

Implantable therapy systems and methods patent, January 1996

Activation and Monitoring of Cellular Transmembrane Potentials patent-application, February 2012

Non-Contact Transfer Printing patent-application, February 2013

Flexible and Stretchable Electronic Systems for Epidermal Electronics patent-application, February 2013

Thermally-activated microchip chemical delivery devices patent, March 2003

Stretchable and Foldable Electronic Devices patent-application, August 2015

Release Strategies for Making Transferable Semiconductor Structures, Devices and Device Components patent-application, December 2011

Methods and devices for fabricating three-dimensional nanoscale structures patent, April 2010

Stretchable and Foldable Electronic Devices patent-application, June 2015

Arrays of ultrathin silicon solar microcells patent, March 2014

Stretchable Electronic Systems With Containment Chambers patent-application, December 2015

Stretchable form of single crystal silicon for high performance electronics on rubber substrates patent, August 2015

Motion compatible sensor for non-invasive optical blood analysis patent, January 2000

Processing Techniques for Silicon-Based Transient Devices patent-application, January 2016

Methods and Devices for Fabricating and Assembling Printable Semiconductor Elements patent-application, July 2014

Self-Similar and Fractal Design for Stretchable Electronics patent-application, December 2015

Methods and devices for fabricating and assembling printable semiconductor elements patent, July 2011

Release strategies for making transferable semiconductor structures, devices and device components patent, April 2011

Composite patterning devices for soft lithography patent, March 2007

Conformable actively multiplexed high-density surface electrode array for brain interfacing patent, January 2015

Transient Electronic Devices Comprising Inorganic Or Hybrid Inorganic And Organic Substrates And Encapsulates patent-application, October 2014

Methods and devices for fabricating and assembling printable semiconductor elements patent, November 2009

Printable semiconductor structures and related methods of making and assembling patent, September 2010

Optical Component Array Having Adjustable Curvature patent-application, October 2012

Biological interface systems with controlled device selector and related methods patent-application, March 2006

Controlled buckling structures in semiconductor interconnects and nanomembranes for stretchable electronics patent, May 2014

Optical systems fabricated by printing-based assembly patent, July 2011

System for Optical Stimulation of Target Cells patent-application, July 2010

Appendage Mountable Electronic Devices COnformable to Surfaces patent-application, December 2013

Materials, Electronic Systems And Modes For Active And Passive Transience patent-application, October 2014

Tissue ablation apparatus with a sliding ablation instrument and method patent-application, July 2002

High resolution sensing and control of electrohydrodynamic jet printing patent, October 2013

Stretchable form of single crystal silicon for high performance electronics on rubber substrates patent, June 2012

Controlled Buckling Structures in Semiconductor Interconnects and Nanomembranes for Stretchable Electronics patent-application, December 2014

High-Speed, High-Resolution Electrophysiology In-Vivo Using Conformal Electronics patent-application, June 2012

Printable, flexible and stretchable diamond for thermal management patent, June 2013

Printable semiconductor structures and related methods of making and assembling patent, October 2011

Stretchable form of single crystal silicon for high performance electronics on rubber substrates patent, April 2009

Release Strategies for Making Transferable Semiconductor Structures, Devices and Device Components patent-application, December 2014

System and Method for Monitoring Cardiorespiratory Parameters patent-application, July 2010

Waterproof stretchable optoelectronics patent-application, June 2012

Methods and devices for fabricating and assembling printable semiconductor elements patent, May 2013

Stretchable and foldable electronic devices patent, October 2013

Optical systems fabricated by printing-based assembly patent, May 2014

Controlled buckling structures in semiconductor interconnects and nanomembranes for stretchable electronics patent, July 2012

Release strategies for making transferable semiconductor structures, devices and device components patent, November 2014

Printable semiconductor structures and related methods of making and assembling patent, March 2013

Implantable biomedical devices on bioresorbable substrates patent, March 2014

Thermally Managed LED Arrays Assembled by Printing patent-application, December 2012

Stretchable form of single crystal silicon for high performance electronics on rubber substrates patent, June 2014

Stretchable Form of Single Crystal Silicon for High Performance Electronics on Rubber Substrates patent-application, January 2016

Printed Assemblies of Ultrathin, Microscale Inorganic Light Emitting Diodes for Deformable and Semitransparent Displays patent-application, May 2015

Printed Assemblies of Ultrathin, Microscale Inorganic Light Emitting Diodes for Deformable and Semitransparent Displays patent-application, December 2010

Storage and dispensing devices for administration of oral transmucosal dosage forms patent-application, July 2008

Capsule-type medical device patent-application, September 2003

High resolution electrohydrodynamic jet printing for manufacturing systems patent, June 2015

Stretchable Form of Single Crystal Silicon for High Performance Electronics on Rubber Substrates patent-application, January 2015

High resolution printing of charge patent, June 2015

Optical systems fabricated by printing-based assembly patent, August 2015

Implantable Biomedical Devices On Bioresorbable Substrates patent-application, September 2011

Methods for Treating Psychiatric Disorders Using Light Energy patent-application, February 2011

Stretchable semiconductor elements and stretchable electrical circuits patent, July 2009

Methods and devices for fabricating and assembling printable semiconductor elements patent, March 2014

Medium scale carbon nanotube thin film integrated circuits on flexible plastic substrates patent, February 2015

High Resolution Electrohydrodynamic Jet Printing for Manufacturing Systems
patent-application, October 2015

Printing-Based Assembly of Multi-Junction, Multi-Terminal Photovoltaic Devices and Related Methods
patent-application, July 2015

Medical implant systems
patent-application, December 2004

Pattern transfer printing by kinetic control of adhesion to an elastomeric stamp
patent, May 2011

Implantable medical device controlled by a non-invasive physiological data measurement device
patent-application, November 2001

Methods of making spatially aligned nanotubes and nanotube arrays
patent, February 2013

Devices and methods for pattern generation by ink lithography
patent-application, March 2008

Multispectral plasmonic crystal sensors
patent, April 2010

Arrays of ultrathin silicon solar microcells
patent, August 2015

Implantable Biomedical Devices on Bioresorbable Substrates
patent-application, June 2014

Printed assemblies of ultrathin, microscale inorganic light emitting diodes for deformable and semitransparent displays
patent, October 2014

Stretchable Electronic Systems With Fluid Containment
patent-application, August 2014

Organ Mounted Electronics
patent-application, May 2015

Implantable therapy systems and methods
patent, January 1996

Activation and Monitoring of Cellular Transmembrane Potentials
patent-application, February 2012

Non-Contact Transfer Printing
patent-application, February 2013

Flexible and Stretchable Electronic Systems for Epidermal Electronics
patent-application, February 2013

Thermally-activated microchip chemical delivery devices
patent, March 2003

Stretchable and Foldable Electronic Devices
patent-application, August 2015

Release Strategies for Making Transferable Semiconductor Structures, Devices and Device Components
patent-application, December 2011

Methods and devices for fabricating three-dimensional nanoscale structures
patent, April 2010

Stretchable and Foldable Electronic Devices
patent-application, June 2015

Arrays of ultrathin silicon solar microcells
patent, March 2014

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patent-application, December 2015

Stretchable form of single crystal silicon for high performance electronics on rubber substrates
patent, August 2015

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patent, January 2000

Processing Techniques for Silicon-Based Transient Devices
patent-application, January 2016

Methods and Devices for Fabricating and Assembling Printable Semiconductor Elements
patent-application, July 2014

Self-Similar and Fractal Design for Stretchable Electronics
patent-application, December 2015

Methods and devices for fabricating and assembling printable semiconductor elements
patent, July 2011

Release strategies for making transferable semiconductor structures, devices and device components
patent, April 2011

Composite patterning devices for soft lithography
patent, March 2007

Conformable actively multiplexed high-density surface electrode array for brain interfacing
patent, January 2015

Transient Electronic Devices Comprising Inorganic Or Hybrid Inorganic And Organic Substrates And Encapsulates
patent-application, October 2014

Methods and devices for fabricating and assembling printable semiconductor elements
patent, November 2009

Printable semiconductor structures and related methods of making and assembling
patent, September 2010

Optical Component Array Having Adjustable Curvature
patent-application, October 2012

Biological interface systems with controlled device selector and related methods
patent-application, March 2006

Controlled buckling structures in semiconductor interconnects and nanomembranes for stretchable electronics
patent, May 2014

Optical systems fabricated by printing-based assembly
patent, July 2011

System for Optical Stimulation of Target Cells
patent-application, July 2010

Appendage Mountable Electronic Devices COnformable to Surfaces
patent-application, December 2013

Materials, Electronic Systems And Modes For Active And Passive Transience
patent-application, October 2014

Tissue ablation apparatus with a sliding ablation instrument and method
patent-application, July 2002

High resolution sensing and control of electrohydrodynamic jet printing
patent, October 2013

Stretchable form of single crystal silicon for high performance electronics on rubber substrates
patent, June 2012

Controlled Buckling Structures in Semiconductor Interconnects and Nanomembranes for Stretchable Electronics
patent-application, December 2014

High-Speed, High-Resolution Electrophysiology In-Vivo Using Conformal Electronics
patent-application, June 2012

Printable, flexible and stretchable diamond for thermal management
patent, June 2013

Printable semiconductor structures and related methods of making and assembling
patent, October 2011

Stretchable form of single crystal silicon for high performance electronics on rubber substrates
patent, April 2009

Release Strategies for Making Transferable Semiconductor Structures, Devices and Device Components
patent-application, December 2014

System and Method for Monitoring Cardiorespiratory Parameters
patent-application, July 2010

Waterproof stretchable optoelectronics
patent-application, June 2012

Methods and devices for fabricating and assembling printable semiconductor elements
patent, May 2013

Stretchable and foldable electronic devices
patent, October 2013

Optical systems fabricated by printing-based assembly
patent, May 2014

Controlled buckling structures in semiconductor interconnects and nanomembranes for stretchable electronics
patent, July 2012

Release strategies for making transferable semiconductor structures, devices and device components
patent, November 2014

Printable semiconductor structures and related methods of making and assembling
patent, March 2013

Implantable biomedical devices on bioresorbable substrates
patent, March 2014

Thermally Managed LED Arrays Assembled by Printing
patent-application, December 2012

Stretchable form of single crystal silicon for high performance electronics on rubber substrates
patent, June 2014

Stretchable Form of Single Crystal Silicon for High Performance Electronics on Rubber Substrates
patent-application, January 2016

Printed Assemblies of Ultrathin, Microscale Inorganic Light Emitting Diodes for Deformable and Semitransparent Displays
patent-application, May 2015

Printed Assemblies of Ultrathin, Microscale Inorganic Light Emitting Diodes for Deformable and Semitransparent Displays
patent-application, December 2010

Storage and dispensing devices for administration of oral transmucosal dosage forms
patent-application, July 2008

Capsule-type medical device
patent-application, September 2003

High resolution electrohydrodynamic jet printing for manufacturing systems
patent, June 2015

Stretchable Form of Single Crystal Silicon for High Performance Electronics on Rubber Substrates
patent-application, January 2015

High resolution printing of charge
patent, June 2015

Optical systems fabricated by printing-based assembly
patent, August 2015

Implantable Biomedical Devices On Bioresorbable Substrates
patent-application, September 2011

Methods for Treating Psychiatric Disorders Using Light Energy
patent-application, February 2011

Stretchable semiconductor elements and stretchable electrical circuits
patent, July 2009

Methods and devices for fabricating and assembling printable semiconductor elements
patent, March 2014

Medium scale carbon nanotube thin film integrated circuits on flexible plastic substrates
patent, February 2015

Conformable Actively Multiplexed High-Density Surface Electrode Array for Brain Interfacing
patent-application, March 2015

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patent-application, June 2013