Cell-based composite materials with programmed structures and functions
Abstract
The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.
- Inventors:
- Issue Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA)
- OSTI Identifier:
- 1637765
- Patent Number(s):
- 10605705
- Application Number:
- 15/950,979
- Assignee:
- National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM); STC.UNM (Albuquerque, NM)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08K - Use of inorganic or non-macromolecular organic substances as compounding ingredients
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- NA0003525
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 04/11/2018
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Kaehr, Bryan J., Brinker, C. Jeffrey, and Townson, Jason L. Cell-based composite materials with programmed structures and functions. United States: N. p., 2020.
Web.
Kaehr, Bryan J., Brinker, C. Jeffrey, & Townson, Jason L. Cell-based composite materials with programmed structures and functions. United States.
Kaehr, Bryan J., Brinker, C. Jeffrey, and Townson, Jason L. Tue .
"Cell-based composite materials with programmed structures and functions". United States. https://www.osti.gov/servlets/purl/1637765.
@article{osti_1637765,
title = {Cell-based composite materials with programmed structures and functions},
author = {Kaehr, Bryan J. and Brinker, C. Jeffrey and Townson, Jason L.},
abstractNote = {The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {3}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Cellular complexity captured in durable silica biocomposites
journal, October 2012
- Kaehr, B.; Townson, J. L.; Kalinich, R. M.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 43, p. 17336-17341
Self-Assembly of Highly Phosphorylated Silaffins and Their Function in Biosilica Morphogenesis
journal, October 2002
- Kröger, Nils; Lorenz, Sonja; Brunner, Eike
- Science, Vol. 298, Issue 5593, p. 584-586
Ambient pressure process for preparing aerogel thin films reliquified sols useful in preparing aerogel thin films
patent, September 1999
- Brinker, Charles Jeffrey; Prakash, Sai
- US Patent Document 5,948,482
Supported inorganic membranes
patent, June 1998
- Sehgal, Rakesh; Brinker, Charles Jeffrey
- US Patent Document 5,772,735
Microparticles with Bimodal Nanoporosity Derived by Microemulsion Templating
journal, December 2009
- Carroll, Nick J.; Pylypenko, Svitlana; Atanassov, Plamen B.
- Langmuir, Vol. 25, Issue 23, p. 13540-13544
Polycationic Peptides from Diatom Biosilica That Direct Silica Nanosphere Formation
journal, November 1999
- Kröger, Nils; Deutzmann, Rainer; Sumper, Manfred
- Science, Vol. 286, Issue 5442, p. 1129-1132
Chitin-Based Organic Networks: An Integral Part of Cell Wall Biosilica in the Diatom Thalassiosira pseudonana
journal, November 2009
- Brunner, Eike; Richthammer, Patrick; Ehrlich, Hermann
- Angewandte Chemie International Edition, Vol. 48, Issue 51, p. 9724-9727
Molecular sieving silica membrane fabrication process
patent, June 1998
- Raman, Narayan K.; Brinker, Charles Jeffrey
- US Patent Document 5,770,275
Hydrothermal synthesis of monodisperse single-crystalline alpha-quartz nanospheres
journal, January 2011
- Jiang, Xingmao; Jiang, Ying-Bing; Brinker, C. Jeffrey
- Chemical Communications, Vol. 47, Issue 26, p. 7524-7526
Solid-state radiation-emitting compositions and devices
patent, August 1992
- Ashley, Carol S.; Brinker, C. Jeffrey; Reed, Scott T.
- US Patent Document 5,137,659
Durable polymer-aerogel based superhydrophobic coatings: a composite material
patent, February 2016
- Kissel, David J.; Brinker, Charles Jeffrey
- US Patent Document 9,249,333
Durable Polymer-Aerogel Based Superhydrophobic Coatings, a Composite Material
patent-application, August 2011
- Kissel, David J.; Baker, Charles Jeffrey
- US Patent Application 13/121150; 20110206925
Inorganic dual-layer microporous supported membranes
patent, March 2003
- Brinker, C. Jeffrey; Tsai, Chung-Yi; Lu, Yungfeng
- US Patent Document 6,536,604
Bioinspired enzyme encapsulation for biocatalysis
journal, October 2008
- Betancor, Lorena; Luckarift, Heather R.
- Trends in Biotechnology, Vol. 26, Issue 10, p. 566-572
Method for making surfactant-templated, high-porosity thin films
patent, August 2001
- Brinker, C. Jeffrey; Lu, Yunfeng; Fan, Hongyou
- US Patent Document 6,270,846
Photoresponsive Release from Azobenzene-Modified Single Cubic Crystal NaCl/Silica Particles
journal, January 2011
- Jiang, Xingmao; Liu, Nanguo; Assink, Roger A.
- Journal of Nanomaterials, Vol. 2011, p. 1-6
Photo-Definable Self-Assembled Materials
patent-application, December 2007
- Doshi, Dhaval; Fan, Hongyou; Huesing, Nicola
- US Patent Application 10/373565; 20070287104
Free-standing mesoporous silica films with tunable chiral nematic structures
journal, November 2010
- Shopsowitz, Kevin E.; Qi, Hao; Hamad, Wadood Y.
- Nature, Vol. 468, Issue 7322, p. 422-425
Method of making dense, conformal, ultra-thin cap layers for nanoporous low-k ILD by plasma assisted atomic layer deposition
patent, May 2011
- Jiang, Ying; Cecchi, Joseph L.; Brinker, C. Jeffrey
- US Patent Document 7,947,579
Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same
patent, February 2017
- Brinker, C. Jeffrey; Carnes, Eric C.; Ashley, Carlee Erin
- US Patent Document 9,579,283
Aerosol Route to Functional Nanostructured Inorganic and Hybrid Porous Materials
journal, October 2010
- Boissiere, Cedric; Grosso, David; Chaumonnot, Alexandra
- Advanced Materials, Vol. 23, Issue 5, p. 599-623
Protein-Directed Assembly of Arbitrary Three-Dimensional Nanoporous Silica Architectures
journal, January 2011
- Khripin, Constantine Y.; Pristinski, Denis; Dunphy, Darren R.
- ACS Nano, Vol. 5, Issue 2, p. 1401-1409
Aerosol method for nano silver-silica composite anti-microbial agent
patent, August 2012
- Jiang, Xingmao; Brinker, C. Jeffrey; Lin, Yong
- US Patent Document 8,246,933
Cell-directed-assembly: Directing the formation of nano/bio interfaces and architectures with living cells
journal, March 2011
- Baca, Helen K.; Carnes, Eric C.; Ashley, Carlee E.
- Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1810, Issue 3, p. 259-267
Interactions of bovine serum albumin and lysozyme with sodium silicate solutions
journal, June 2003
- Coradin, Thibaud; Coupé, Aurélie; Livage, Jacques
- Colloids and Surfaces B: Biointerfaces, Vol. 29, Issue 2-3, p. 189-196
A Novel Method for Enzyme Immobilization: Direct Encapsulation of Acid Phosphatase in Nanoporous Silica Host Materials
journal, March 2001
- Wei, Yen; Xu, Jigeng; Feng, Qiuwei
- Journal of Nanoscience and Nanotechnology, Vol. 1, Issue 1, p. 83-93
Hollow Sphere Metal Oxides
patent-application, September 2008
- Jiang, Xingmao; Baker, Charles Jeffrey
- US Patent Application 11/876338; 20080210053
Low temperature process for obtaining thin glass films
patent, October 1984
- Brinker, C. Jeffrey; Reed, Scott T.
- US Patent Document 4,476,156
Cell-based composite materials with programmed structures and functions
patent, March 2016
- Kaehr, Bryan James; Brinker, C. Jeffrey; Townson, Jason L.
- US Patent Document 9,273,305
Method to create gradient index in a polymer
patent, October 2014
- Dirk, Shawn M.; Johnson, Ross S.; Boye, Robert
- US Patent Document 8,859,190
Prescribing diatom morphology: toward genetic engineering of biological nanomaterials
journal, December 2007
- Kröger, Nils
- Current Opinion in Chemical Biology, Vol. 11, Issue 6, p. 662-669
Inorganic-polymer-derived dielectric films
patent, March 1987
- Brinker, C. Jeffrey; Keefer, Keith D.; Lenahan, Patrick M.
- US Patent Document 4,652,467
Durable polymer-aerogel based superhydrophobic coatings, a composite material
patent, March 2014
- Kissel, David J.; Brinker, Charles Jeffrey
- US Patent Document 8,663,742
Biomimetic dual templating of silica by polysaccharide/protein assemblies
journal, August 2008
- Gautier, Clémentine; Abdoul-Aribi, Nora; Roux, Cécile
- Colloids and Surfaces B: Biointerfaces, Vol. 65, Issue 1, p. 140-145
Comparison of hexamethyldisilazane (HMDS), Peldri II, and critical-point drying methods for scanning electron microscopy of biological specimens
journal, December 1993
- Bray, D. F.; Bagu, J.; Koegler, P.
- Microscopy Research and Technique, Vol. 26, Issue 6, p. 489-495
On the role(s) of additives in bioinspired silicification
journal, January 2005
- Patwardhan, Siddharth V.; Clarson, Stephen J.; Perry, Carole C.
- Chemical Communications, Vol. 0, Issue 9, p. 1113-1121
Porous Nanoparticle Supported Lipid Bilayer Nanostructures
patent-application, November 2011
- Liu, Juewen; Brinker, Jeffrey C.; Ashley, Carlee
- US Patent Document 13/143164; 20110268791
Bioreactor systems for the production of biopharmaceuticals from animal cells
journal, September 2006
- Warnock, James N.; Al-Rubeai, Mohamed
- Biotechnology and Applied Biochemistry, Vol. 45, Issue 1, p. 1-12
Porous Nanoparticle-Supported Lipid Bilayers (Protocells) for Targeted Delivery Including Transdermal Delivery of Cargo and Methods Thereof
patent-application, August 2017
- Ashley, Carlee Erin; Brinker, C. Jeffrey; Carnes, Eric C.
- US Patent Application 15/380962; 20170232115
Self-assembly of water-soluble nanocrystals
patent, January 2012
- Fan, Hongyou; Brinker, C. Jeffrey; Lopez, Gabriel P.
- US Patent Document 8,092,595
Prototyping of Patterned Functional Nanostructures
patent-application, April 2002
- Fan, Hongyou; Lopez, Gabriel P.; Brinker, Charles Jeffrey
- US Patent Application 09/838153; 20020046682
Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism
journal, October 1992
- Kresge, C. T.; Leonowicz, M. E.; Roth, W. J.
- Nature, Vol. 359, Issue 6397, p. 710-712
CRLF-2 Binding Peptides, Protocells and Viral-Like Particles Useful in the Treatment of Cancer, Including Acute Lymphoblastic Leukemia (All)
patent-application, January 2015
- Brinker, C. Jeffrey; Peabody, David S.; Wharton, Walker Kip
- US Patent Application 14/369741; 20150010475
Evaporation-Induced Self-Assembly of Hybrid Bridged Silsesquioxane Film and Particulate Mesophases with Integral Organic Functionality
journal, June 2000
- Lu, Yunfeng; Fan, Hongyou; Doke, Nilesh
- Journal of the American Chemical Society, Vol. 122, Issue 22, p. 5258-5261
Cell-Directed Assembly of Lipid-Silica Nanostructures Providing Extended Cell Viability
journal, July 2006
- Baca, Helen K.; Ashley, Carlee; Carnes, Eric
- Science, Vol. 313, Issue 5785, p. 337-341
Aerosol fabrication of hollow mesoporous silica nanoparticles and encapsulation of l-methionine as a candidate drug cargo
journal, January 2010
- Jiang, Xingmao; Ward, Timothy L.; Cheng, Yung-Sung
- Chemical Communications, Vol. 46, Issue 17, p. 3019-3021
Photo-Definable Self-Assembled Materials
patent-application, September 2002
- Doshi, Dhaval; Fan, Hongyou; Huesing, Nicola
- US Patent Application 10/100108; 20020127498
Hollow sphere metal oxides
patent, June 2010
- Jiang, Xingmao; Brinker, Charles Jeffrey
- US Patent Document 7,744,673
Method of Making Dense, Conformal, Ultra-Thin Cap Layers for Nanoporous Low-K ILD by Plasma Assisted Atomic Layer Deposition
patent-application, August 2007
- Jiang, Ying BIng; Cecchi, Jospeh L.; Brinker, C. Jeffrey
- US Patent Application 11/673190; 20070190777
Encapsulation of functional cells by sol–gel silica: actual progress and perspectives for cell therapy
journal, January 2004
- Carturan, Giovanna; Dal Toso, Roberto; Boninsegna, Sara
- J. Mater. Chem., Vol. 14, Issue 14
Biocompatible Microfabrication of 3D Isolation Chambers for Targeted Confinement of Individual Cells and Their Progeny
journal, September 2012
- Harper, Jason C.; Brozik, Susan M.; Brinker, C. Jeffrey
- Analytical Chemistry, Vol. 84, Issue 21, p. 8985-8989
Process to form mesostructured films
patent, January 1999
- Brinker, C. Jeffrey; Anderson, Mark T.; Ganguli, Rahul
- US Patent Document 5,858,457
Methods for preparing high crystallinity and surface area porous metal oxides
patent, November 2012
- Jiang, Xingmao; Brinker, C. Jeffrey
- US Patent Document 8,318,127
Synthesis of inorganic materials with complex form
journal, July 1996
- Mann, Stephen; Ozin, Geoffrey A.
- Nature, Vol. 382, Issue 6589, p. 313-318
Silica replication of the hierarchical structure of wood with nanometer precision
journal, May 2011
- Van Opdenbosch, Daniel; Fritz-Popovski, Gerhard; Paris, Oskar
- Journal of Materials Research, Vol. 26, Issue 10, p. 1193-1202
Porous Nanoparticle Supported Lipid Bilayers (Protocells) as Delivery Vehicles
journal, February 2009
- Liu, Juewen; Stace-Naughton, Alison; Jiang, Xingmao
- Journal of the American Chemical Society, Vol. 131, Issue 4, p. 1354-1355
Bio-Inspired Materials - Mining the Old Literature for New Ideas
journal, September 2010
- Fratzl, Peter; Weiner, Steve
- Advanced Materials, Vol. 22, Issue 41, p. 4547-4550
Coatings with controlled porosity and chemical properties
patent, July 1993
- Frye, Gregory C.; Brinker, C. Jeffrey; Doughty, Daniel H.
- US Patent Document 5,224,972
Mechanically Encoded Cellular Shapes for Synthesis of Anisotropic Mesoporous Particles
journal, September 2014
- Meyer, Kristin C.; Coker, Eric N.; Bolintineanu, Dan S.
- Journal of the American Chemical Society, Vol. 136, Issue 38, p. 13138-13141
Cell-Specific Delivery of Diverse Cargos by Bacteriophage MS2 Virus-like Particles
journal, June 2011
- Ashley, Carlee E.; Carnes, Eric C.; Phillips, Genevieve K.
- ACS Nano, Vol. 5, Issue 7, p. 5729-5745
Synthetic fossilization of soft biological tissues and their shape-preserving transformation into silica or electron-conductive replicas
journal, December 2014
- Townson, Jason L.; Lin, Yu-Shen; Chou, Stanley S.
- Nature Communications, Vol. 5, Article No. 5665
Coatings with controlled porosity and chemical properties
patent, December 1996
- Frye, Gregory C.; Brinker, C. Jeffrey; Doughty, Daniel H.
- US Patent Document 5,589,396
Method of Making Dense, Conformal, Ultra-Thin Cap Layers for Nanoporous Low-K ILD by Plasma Assisted Atomic Layer Deposition
patent-application, August 2011
- Jiang, Ying-Bing; Cecchi, Joseph L.; Brinker, C. Jeffrey
- US Patent Document 13/083790; 20110186971
Morphological Control in Colloidal Crystal Templating of Inverse Opals, Hierarchical Structures, and Shaped Particles
journal, February 2008
- Stein, Andreas; Li, Fan; Denny, Nicholas R.
- Chemistry of Materials, Vol. 20, Issue 3, p. 649-666
Composition containing aerogel substrate loaded with tritium
patent, January 1992
- Ashley, Carol S.; Brinker, C. Jeffrey; Ellefson, Robert E.
- US Patent Document 5,078,919
Photo-definable self-assembled materials
patent, February 2008
- Doshi, Dhaval A.; Fan, Hongyou; Huesing, Nicola
- US Patent Document 7,332,264
Protocells and their use for targeted delivery of multicomponent cargos to cancer cells
patent, March 2015
- Brinker, C. Jeffrey; Ashley, Carlee Erin; Jiang, Xingmao
- US Patent Document 8,992,984
Protocells and Their Use for Targeted Delivery of Multicomponent Cargos to Cancer Cells
patent-application, June 2015
- Brinker, C. Jeffrey; Ashley, Carlee Erin; Jiang, Xingmao
- US Patent Application 14/627739; 20150164798
Organic Templates for the Generation of Inorganic Materials
journal, March 2003
- van Bommel, Kjeld J. C.; Friggeri, Arianna; Shinkai, Seiji
- Angewandte Chemie International Edition, Vol. 42, Issue 9, p. 980-999
Carriers for Plasmid and RNP Delivery in the Treatment of Cancer and Other Disease States
patent-application, February 2018
- Brinker, Charles Jeffrey; Carnes, Eric C.; Ashley, Carlee Erin
- US Patent Application 15/474810; 20180049984
Porous Nanoparticle-Supported Lipid Bilayers (Photocells) for Targeted Delivery and Methods of Using Same
patent-application, March 2014
- Brinker, C. Jeffrey; Carnes, Eric C.; Ashley, Carleen Erin
- US Patent Application 14/113371; 20140079774
Process for making solid-state radiation-emitting composition
patent, August 1993
- Ashley, Carol S.; Brinker, C. Jeffrey; Reed, Scott T.
- US Patent Document 5,240,647
Diatoms, Biomineralization Processes, and Genomics
journal, November 2008
- Hildebrand, Mark
- Chemical Reviews, Vol. 108, Issue 11, p. 4855-4874
Superhydrophobic Aerogel That Does Not Require Per-Fluoro Compounds or Contain Any Fluorine
patent-application, February 2012
- Kissel, David J.; Brinker, Charles Jeffrey
- US Patent Document 13/121166; 20120040577
Method for making surfactant-templated thin films
patent, May 2002
- Brinker, C. Jeffrey; Lu, Yunfeng; Fan, Hongyou
- US Patent Document 6,387,453
Method for net-shaping using aerogels
patent, July 2001
- Brinker, C. Jeffrey; Ashey, Carol S.; Reed, Scott T.
- US Patent Document 6,258,305
Cell-Directed Assembly of Bio/Nano Interfaces—A New Scheme for Cell Immobilization
journal, September 2007
- Baca, Helen K.; Carnes, Eric; Singh, Seema
- Accounts of Chemical Research, Vol. 40, Issue 9, p. 836-845
Protocells and Their Use for Target Delivery of Multicomponent Cargos to Cancer Cells
patent-application, November 2013
- Brinker, C. Jeffrey; Ashley, Carlee Erin; Jiang, Xingmao
- US Patent Application 14/797487; 20150320681
Chemical reduction of three-dimensional silica micro-assemblies into microporous silicon replicas
journal, March 2007
- Bao, Zhihao; Weatherspoon, Michael R.; Shian, Samuel
- Nature, Vol. 446, Issue 7132, p. 172-175
Enzymatically active high-flux selectively gas-permeable membranes
patent, January 2016
- Jiang, Ying; Cecchi, Joseph L.; Rempe, Susan
- US Patent Document 9,242,210
Molecular sieving silica membrane fabrication process
patent, August 1999
- Raman, Narayan K.; Brinker, Charles Jeffrey
- US Patent Document 5,935,646
Encapsulation of S. cerevisiae in Poly(glycerol) Silicate Derived Matrices: Effect of Matrix Additives and Cell Metabolic Phase on Long-Term Viability and Rate of Gene Expression
journal, May 2011
- Harper, Jason C.; Lopez, DeAnna M.; Larkin, Elizabeth C.
- Chemistry of Materials, Vol. 23, Issue 10, p. 2555-2564
Porous nanoparticle supported lipid bilayer nanostructures
patent, May 2014
- Liu, Juewen; Brinker, Jeffrey C.; Ashley, Carlee Erin
- US Patent Document 8,734,816
Durable Polymer-Aerogel Based Superhydrophobic Coatings: a Composite Material
patent-application, May 2014
- Kissell, David J.; Baker, Charles Jeffrey
- US Patent Application 14/157918; 20140134907
Biomimetics and Biotemplating of Natural Materials
journal, March 2010
- Paris, Oskar; Burgert, Ingo; Fratzl, Peter
- MRS Bulletin, Vol. 35, Issue 3, p. 219-225
Hierarchical architectures by synergy between dynamical template self-assembly and biomineralization
journal, May 2007
- Pouget, Emilie; Dujardin, Erik; Cavalier, Annie
- Nature Materials, Vol. 6, Issue 6, p. 434-439
Inorganic volumetric light source excited by ultraviolet light
patent, April 1994
- Reed, Scott T.; Walko, Robert J.; Ashley, Carol S.
- US Patent Document 5,306,445
Toroidal mesoporous silica nanoparticles (TMSNPs) and related protocells
patent, January 2018
- Brinker, C. Jeffrey; Lin, Yu-Shen
- US Patent Document 9,855,217
Recent bio-applications of sol–gel materials
journal, January 2006
- Avnir, David; Coradin, Thibaud; Lev, Ovadia
- Journal of Materials Chemistry, Vol. 16, Issue 11, p. 1013-1030
Electrostatically Mediated Liposome Fusion and Lipid Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and Delivery
journal, June 2009
- Liu, Juewen; Jiang, Xingmao; Ashley, Carlee
- Journal of the American Chemical Society, Vol. 131, Issue 22, p. 7567-7569
Antibiotic Protocells and Related Pharmaceutical Formulations and Methods of Treatment
patent-application, June 2017
- Ashley, Carlee Erin; Carnes, Eric C.; Wu, Terry
- US Patent Application 14/781817; 20170165375
Synthesis of Macroporous Minerals with Highly Ordered Three-Dimensional Arrays of Spheroidal Voids
journal, July 1998
- Holland, Brian T.; Blanford, Christopher F.; Stein, Andreas
- Science, Vol. 281, Issue 5376, p. 538-540
Method for atomic layer deposition
patent, March 2017
- Jiang, Ying; Cecchi, Joseph L.; Fu, Yaqin
- US Patent Document 9,605,344
Encapsulation of cells within silica matrixes: Towards a new advance in the conception of living hybrid materials
journal, February 2010
- Meunier, Christophe F.; Dandoy, Philippe; Su, Bao-Lian
- Journal of Colloid and Interface Science, Vol. 342, Issue 2, p. 211-224
Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord
journal, June 2013
- Dengler, Ellen C.; Liu, Juewen; Kerwin, Audra
- Journal of Controlled Release, Vol. 168, Issue 2, p. 209-224
Photo-definable self-assembled materials
patent, October 2004
- Doshi, Dhaval A.; Fan, Hongyou; Huesing, Nicola
- US Patent Document 6,808,867
Porous Nanoparticle-Supported Lipid Bilayers (Protocells) for Targeted Delivery and Methods of Using Same
patent-application, April 2016
- Brinker, C. Jeffrey; Carnes, Eric C.; Ashley, Carlee Erin
- US Patent Application 14/970998; 20160106671
Fluid light guide having hydrophobic aerogel cladding layer
patent, January 2006
- Fraval, Hanafi; Brinker, C. Jeffrey
- US Patent Document 6,983,093
Diatomaceous Lessons in Nanotechnology and Advanced Materials
journal, August 2009
- Losic, Dusan; Mitchell, James G.; Voelcker, Nicolas H.
- Advanced Materials, Vol. 21, Issue 29, p. 2947-2958
Porous Nanoparticle Supported Lipid Nanostructures
patent-application, October 2014
- Liu, Juewen; Brinker, C. Jeffrey; Ashley, Carlee
- US Patent Application 14/253030; 20140301951
Mesoporous Alum Nanoparticles as a Universal Platform for Antigen Adsorption, Presentation and Delivery
patent-application, June 2016
- Carnes, Eric C.; Brinker, C. Jeffrey; Ashley, Carlee Erin
- US Patent Application 14/781765; 20160151482
Hydrophobic Organic-Inorganic Hybrid Silane Coatings
patent-application, May 2008
- Shah, Pratik; Brinker, Jeffrey; Koene, Bryan
- US Patent Application 11/934238; 20080113188
Modification of the physical and optical properties of the frustule of the diatom Coscinodiscus wailesii by nickel sulfate
journal, June 2007
- Townley, Helen E.; Woon, Kai Lin; Payne, Frank P.
- Nanotechnology, Vol. 18, Issue 29, Article No. 295101
Prototyping of patterned functional nanostructures
patent, October 2002
- Fan, Hongyou; Lopez, Gabriel P.; Brinker, Charles Jeffrey
- US Patent Document 6,471,761
Ultra-thin microporous/hybrid materials
patent, May 2012
- Jiang, Ying; Cecchi, Joseph L.; Brinker, C. Jeffrey
- US Patent Document 8,187,678
Core and Surface Modification of Mesoporous Silica Nanoparticles to Achieve Cell Specific Targeting In Vivo.
patent-application, October 2016
- Brinker, Charles Jeffrey; Townson, Jason; Lin, Yu-Shen
- US Patent Application 15/023093; 20160287717
Peptide-Based Methods for the Preparation of Nanostructured Inorganic Materials
journal, February 2010
- Chen, Chun-Long; Rosi, Nathaniel L.
- Angewandte Chemie International Edition, Vol. 49, Issue 11, p. 1924-1942
Silicon-Based Proton Exchange Membrane (PEM) and Method of Making a Silicon-Based PEM
patent-application, January 2014
- Moghaddam, Saeed; Shannon, Mark A.
- US Patent Application 13/289595; 20140023956
Extensive and Intimate Association of the Cytoskeleton with Forming Silica in Diatoms: Control over Patterning on the Meso- and Micro-Scale
journal, December 2010
- Tesson, Benoit; Hildebrand, Mark; Sokolov, Igor
- PLoS ONE, Vol. 5, Issue 12, Article No. e14300
Prototyping of patterned functional nanostructures
patent, July 2005
- Fan, Hongyou; Lopez, Gabriel P.; Brinker, Charles Jeffrey
- US Patent Document 6,913,832
Preparation of high porosity xerogels by chemical surface modification.
patent, October 1996
- Deshpande, Ravindra; Smith, Douglas M.; Brinker, C. Jeffrey
- US Patent Document 5,565,142
Superhydrophobic Aerogel that Does Not Require Per-Fluoro Compounds or Contain Any Fluorine
patent-application, August 2015
- Kissel, David J.; Brinker, Charles Jeffrey
- US Patent Application 14/678533; 20150240123
Preparation of hydrophobic coatings
patent, February 2009
- Branson, Eric D.; Shah, Pratik; Singh, Seema
- US Patent Document 7,485,343
Torroidal Mesoporous Silica Nanoparticles (TMSNPS) and Related Protocells
patent-application, November 2016
- Brinker, C. Jeffrey; Lin, Yu-Shen
- US Patent Application 15/023110; 20160338954
Molecular receptors in metal oxide sol-gel materials prepared via molecular imprinting
patent, May 2000
- Sasaki, Darryl Y.; Brinker, C. Jeffrey; Ashley, Carol S.
- US Patent Document 6,057,377
Method for making surfactant-templated thin films
patent, August 2010
- Brinker, C. Jeffrey; Lu, Yunfeng; Fan, Hong
- US Patent Document RE41,612
Freezing assisted fabrication of nano and micro hollow cubic metal oxides
patent, August 2013
- Jiang, Xingmao; Brinker, C. Jeffrey
- US Patent Document 8,501,057
Porous Nanoparticle-Supported Lipid Bilayers (Protocells) for Targeted Delivery Including Transdermal Delivery of Cargo and Methods thereof
patent-application, October 2015
- Ashley, Carlee Erin; Brinker, C. Jeffrey; Carnes, Eric C.
- US Patent Application 14/350674; 20150272885
Nanopatterned protein microrings from a diatom that direct silica morphogenesis
journal, February 2011
- Scheffel, A.; Poulsen, N.; Shian, S.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 8, p. 3175-3180
Infiltration of Silica Inside Fibrillar Collagen
journal, October 2011
- Niu, Li-na; Jiao, Kai; Qi, Yi-pin
- Angewandte Chemie International Edition, Vol. 50, Issue 49, p. 11688-11691
Inorganic Dual-Layer Microporous Supported Membranes
patent-application, October 2002
- Brinker, C. Jeffrey; Tsai, Chung-Yi; Lu, Yunfeng
- US Patent Application 10/104551; 20020142172
Innovative nanopore sequencing technology including a self-assembled porous membrane
patent, March 2018
- Brueck, Steven R. J.; Edwards, Jeremy Scott; Neumann, Alexander
- US Patent Document 9,927,397
Assembly of large-area, highly ordered, crack-free inverse opal films
journal, May 2010
- Hatton, B.; Mishchenko, L.; Davis, S.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 23, p. 10354-10359
Luminescent light source for laser pumping and laser system containing same
patent, May 1994
- Hamil, Roy A.; Ashley, Carol S.; Brinker, C. Jeffrey
- US Patent Document 5,313,485
Protocells for Plasmid and RNP Delivery in the Treatment of Cancer and Other Disease States
patent-application, February 2018
- Brinker, Charles Jeffrey; Carnes, Eric C.; Ashley, Carlee Erin
- US Patent Application 15/474800; 20180028686
Cell-Directed Integration into Three-Dimensional Lipid−Silica Nanostructured Matrices
journal, September 2010
- Harper, Jason C.; Khirpin, Constantine Y.; Carnes, Eric C.
- ACS Nano, Vol. 4, Issue 10, p. 5539-5550
Understanding enzyme immobilisation
journal, January 2009
- Hanefeld, Ulf; Gardossi, Lucia; Magner, Edmond
- Chemical Society Reviews, Vol. 38, Issue 2, p. 453-468
Orthogonal Cell-Based Biosensing: Fluorescent, Electrochemical, and Colorimetric Detection with Silica-Immobilized Cellular Communities Integrated with an ITO-Glass/Plastic Laminate Cartridge
journal, June 2012
- Harper, Jason C.; Edwards, Thayne L.; Savage, Travis
- Small, Vol. 8, Issue 17, p. 2743-2751
Preparation and Physisorption Characterization of d -Glucose-Templated Mesoporous Silica Sol−Gel Materials
journal, August 1999
- Wei, Yen; Xu, Jigeng; Dong, Hua
- Chemistry of Materials, Vol. 11, Issue 8, p. 2023-2029
An inorganic–organic proton exchange membrane for fuel cells with a controlled nanoscale pore structure
journal, February 2010
- Moghaddam, Saeed; Pengwang, Eakkachai; Jiang, Ying-Bing
- Nature Nanotechnology, Vol. 5, Issue 3, p. 230-236
Simple and mild preparation of silica-enzyme composites from silicic acid solution
journal, January 2009
- Bassindale, Alan R.; Taylor, Peter G.; Abbate, Vincenzo
- Journal of Materials Chemistry, Vol. 19, Issue 41, p. 7606-7609
Durable Polymer-Aerogel Based Superhydrophobic Coatings: A Composite Material
patent-application, May 2016
- Kissel, David J.; Brinker, Charles Jeffrey
- US Patent Application 14/981400; 20160130449
Method for Atomic Layer Deposition
patent-application, August 2016
- Jiang, Ying-Bing; Cecchi, Joseph L.; Fu, Yaqin
- US Patent Application 14/917566; 20160222512
Species-specific polyamines from diatoms control silica morphology
journal, December 2000
- Kroger, N.; Deutzmann, R.; Bergsdorf, C.
- Proceedings of the National Academy of Sciences, Vol. 97, Issue 26, p. 14133-14138
Scale-up analysis for a CHO cell culture process in large-scale bioreactors
journal, July 2009
- Xing, Zizhuo; Kenty, Brian M.; Li, Zheng Jian
- Biotechnology and Bioengineering, Vol. 103, Issue 4, p. 733-746
Sol-gel method for encapsulating molecules
patent, December 2002
- Brinker, C. Jeffrey; Ashley, Carol S.; Bhatia, Rimple
- US Patent Document 6,495,352
Superhydrophobic aerogel that does not require per-fluoro compounds or contain any fluorine
patent, May 2015
- Kissel, David J.; Brinker, Charles Jeffrey
- US Patent Document 9,040,435
Ultra-Thin Microporous/Hybrid Materials
patent-application, July 2010
- Jiang, Ying-Bing; Cecchi, Joseph L.; Brinker, C. Jeffrey
- US Patent Application 12/271719; 20100178468
Protocells and their use for targeted delivery of multicomponent cargos to cancer cells
patent, November 2016
- Brinker, C. Jeffrey; Ashley, Carlee Erin; Jiang, Xingmao
- US Patent Document 9,480,653
Drying cells for SEM, AFM and TEM by hexamethyldisilazane: a study on hepatic endothelial cells
journal, April 1997
- Braet, F.; De Zanger, R.; Wisse, E.
- Journal of Microscopy, Vol. 186, Issue 1, p. 84-87
Aerosol-assisted self-assembly of mesostructured spherical nanoparticles
journal, March 1999
- Lu, Yunfeng; Fan, Hongyou; Stump, Aaron
- Nature, Vol. 398, Issue 6724, p. 223-226
Fluid Light Guide
patent-application, March 2003
- Fravel, Hanafi R.; Brinker, C. Jeffrey
- US Patent Application 09/920570; 20030044149
Solid-state radiation-emitting compositions and devices
patent, June 1992
- Ashley, Carol S.; Brinker, C. Jeffrey; Reed, Scott T.
- US Patent Document 5,122,305
Hydrogel-Based Non-Autologous Cell and Tissue Therapy
journal, September 2000
- Zimmermann, U.; Mimietz, S.; Zimmermann, H.
- BioTechniques, Vol. 29, Issue 3
A new family of mesoporous molecular sieves prepared with liquid crystal templates
journal, December 1992
- Beck, J. S.; Vartuli, J. C.; Roth, W. J.
- Journal of the American Chemical Society, Vol. 114, Issue 27, p. 10834-10843
Protein- and Peptide-Directed Syntheses of Inorganic Materials
journal, November 2008
- Dickerson, Matthew B.; Sandhage, Kenneth H.; Naik, Rajesh R.
- Chemical Reviews, Vol. 108, Issue 11, p. 4935-4978
Aerosol Method for Nano Silver-Silica Composite Anti-Microbial Agent
patent-application, July 2009
- Jiang, Xingmao; Brinker, C. Jeffrey; Lin, Yong
- US Patent Application 12/324318; 20090175948
Calcium-dependent Clustering of Inositol 1,4,5-Trisphosphate Receptors
journal, June 1998
- Wilson, Bridget S.; Pfeiffer, Janet R.; Smith, Alexander J.
- Molecular Biology of the Cell, Vol. 9, Issue 6, p. 1465-1478
Encapsulation of living tissue cells in inorganic microspheres prepared from an organosilicon
patent, April 1999
- Pope, Edward J. A.
- US Patent Document 5,895,757
Aerosol fabrication methods for monodisperse nanoparticles
patent, October 2014
- Jiang, Xingmao; Brinker, C. Jeffrey
- US Patent Document 8,864,045
Development and characterization of 3D, nano-confined multicellular constructs for advanced biohybrid devices.
report, September 2011
- Kaehr, Bryan James
- SAND2011-6892
Prototyping of Patterned Functional Nanostructures
patent-application, February 2003
- Fan, Hongyou; Lopez, Gabriel P.; Baker, Charles Jeffrey
- US Patent Application 10/163425; 20030039744
Aerosol-assisted synthesis of monodisperse single-crystalline α-cristobalite nanospheres
journal, January 2012
- Jiang, Xingmao; Bao, Lihong; Cheng, Yung-Sung
- Chemical Communications, Vol. 48, Issue 9, p. 1293-1295
Prospects of Manipulating Diatom Silica Nanostructure
journal, January 2005
- Hildebrand, Mark
- Journal of Nanoscience and Nanotechnology, Vol. 5, Issue 1, p. 146-157
Proteins in Mesoporous Silicates
journal, October 2008
- Hudson, Sarah; Cooney, Jakki; Magner, Edmond
- Angewandte Chemie International Edition, Vol. 47, Issue 45, p. 8582-8594
Molecular sieve sensors for selective detection at the nanogram level
patent, September 1992
- Bein, Thomas W.; Brown, Kelly D.; Frye, Gregory C.
- US Patent Document 5,151,110
Biomimetic membranes and methods of making biomimetic membranes
patent, November 2016
- Rempe, Susan; Brinker, C. Jeffrey; Rogers, David Michael
- US Patent Document 9,486,742
Self-assembly of nanocomposite materials
patent, July 2001
- Brinker, C. Jeffrey; Sellinger, Alan; Lu, Yunfeng
- US Patent Document 6,264,741
DNA translocation through an array of kinked nanopores
journal, August 2010
- Chen, Zhu; Jiang, Yingbing; Dunphy, Darren R.
- Nature Materials, Vol. 9, Issue 8, p. 667-675
Application of AFM in understanding biomineral formation in diatoms
journal, December 2007
- Hildebrand, Mark; Doktycz, Mitchel J.; Allison, David P.
- Pflügers Archiv - European Journal of Physiology, Vol. 456, Issue 1, p. 127-137
Silicatein filaments and subunits from a marine sponge direct the polymerization of silica and silicones in vitro
journal, January 1999
- Cha, J. N.; Shimizu, K.; Zhou, Y.
- Proceedings of the National Academy of Sciences, Vol. 96, Issue 2, p. 361-365
SiO2 Entrapment of Animal Cells for Hybrid
Bioartificial Organs
journal, January 2000
- Carturan, Giovanni; Dal Monte, Renzo; Muraca, Maurizio
- MRS Proceedings, Vol. 628
Uncooled thin film pyroelectric IR detector with aerogel thermal isolation
patent, September 1999
- Ruffner, Judith A.; Bullington, Jeff; Clem, Paul G.
- US Patent Document 5,949,071