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Title: Cell-based composite materials with programmed structures and functions

Abstract

The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.

Inventors:
; ;
Issue Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1637765
Patent Number(s):
10605705
Application Number:
15/950,979
Assignee:
National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM); STC.UNM (Albuquerque, NM)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08K - Use of inorganic or non-macromolecular organic substances as compounding ingredients
DOE Contract Number:  
NA0003525
Resource Type:
Patent
Resource Relation:
Patent File Date: 04/11/2018
Country of Publication:
United States
Language:
English

Citation Formats

Kaehr, Bryan J., Brinker, C. Jeffrey, and Townson, Jason L. Cell-based composite materials with programmed structures and functions. United States: N. p., 2020. Web.
Kaehr, Bryan J., Brinker, C. Jeffrey, & Townson, Jason L. Cell-based composite materials with programmed structures and functions. United States.
Kaehr, Bryan J., Brinker, C. Jeffrey, and Townson, Jason L. Tue . "Cell-based composite materials with programmed structures and functions". United States. https://www.osti.gov/servlets/purl/1637765.
@article{osti_1637765,
title = {Cell-based composite materials with programmed structures and functions},
author = {Kaehr, Bryan J. and Brinker, C. Jeffrey and Townson, Jason L.},
abstractNote = {The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2020},
month = {3}
}