Global to push GA events into
skip to main content

Title: Cell-based composite materials with programmed structures and functions

The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.
; ;
Issue Date:
OSTI Identifier:
National Technology Engineering Solutions of Sandia, LLC (Albuquerque, NM) SNL-A
Patent Number(s):
Application Number:
Contract Number:
Resource Relation:
Patent File Date: 2016 Jan 14
Research Org:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org:
Country of Publication:
United States

Works referenced in this record:

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers
journal, April 2011
  • Ashley, Carlee E.; Carnes, Eric C.; Phillips, Genevieve K.
  • Nature Materials, Vol. 10, Issue 5, p. 389-397
  • DOI: 10.1038/nmat2992

Cell-directed-assembly: Directing the formation of nano/bio interfaces and architectures with living cells
journal, March 2011
  • Baca, Helen K.; Carnes, Eric C.; Ashley, Carlee E.
  • Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1810, Issue 3, p. 259-267
  • DOI: 10.1016/j.bbagen.2010.09.005

Chemical reduction of three-dimensional silica micro-assemblies into microporous silicon replicas
journal, March 2007
  • Bao, Zhihao; Weatherspoon, Michael R.; Shian, Samuel
  • Nature, Vol. 446, Issue 7132, p. 172-175
  • DOI: 10.1038/nature05570

A new family of mesoporous molecular sieves prepared with liquid crystal templates
journal, December 1992
  • Beck, J. S.; Vartuli, J. C.; Roth, W. J.
  • Journal of the American Chemical Society, Vol. 114, Issue 27, p. 10834-10843
  • DOI: 10.1021/ja00053a020

Bioinspired enzyme encapsulation for biocatalysis
journal, October 2008

Aerosol Route to Functional Nanostructured Inorganic and Hybrid Porous Materials
journal, October 2010
  • Boissiere, Cedric; Grosso, David; Chaumonnot, Alexandra
  • Advanced Materials, Vol. 23, Issue 5, p. 599-623
  • DOI: 10.1002/adma.201001410

Evaporation-Induced Self-Assembly: Nanostructures Made Easy
journal, May 1999

Chitin-Based Organic Networks: An Integral Part of Cell Wall Biosilica in the Diatom Thalassiosira pseudonana
journal, November 2009
  • Brunner, Eike; Richthammer, Patrick; Ehrlich, Hermann
  • Angewandte Chemie International Edition, Vol. 48, Issue 51, p. 9724-9727
  • DOI: 10.1002/anie.200905028

Microparticles with Bimodal Nanoporosity Derived by Microemulsion Templating
journal, December 2009
  • Carroll, Nick J.; Pylypenko, Svitlana; Atanassov, Plamen B.
  • Langmuir, Vol. 25, Issue 23, p. 13540-13544
  • DOI: 10.1021/la900988j

Peptide-Based Methods for the Preparation of Nanostructured Inorganic Materials
journal, February 2010
  • Chen, Chun-Long; Rosi, Nathaniel L.
  • Angewandte Chemie International Edition, Vol. 49, Issue 11, p. 1924-1942
  • DOI: 10.1002/anie.200903572

Interactions of bovine serum albumin and lysozyme with sodium silicate solutions
journal, June 2003
  • Coradin, Thibaud; Coupé, Aurélie; Livage, Jacques
  • Colloids and Surfaces B: Biointerfaces, Vol. 29, Issue 2-3, p. 189-196
  • DOI: 10.1016/S0927-7765(02)00208-4

Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord
journal, June 2013

Bio-Inspired Materials - Mining the Old Literature for New Ideas
journal, September 2010
  • Fratzl, Peter; Weiner, Steve
  • Advanced Materials, Vol. 22, Issue 41, p. 4547-4550
  • DOI: 10.1002/adma.201002127

Biomimetic dual templating of silica by polysaccharide/protein assemblies
journal, August 2008
  • Gautier, Clémentine; Abdoul-Aribi, Nora; Roux, Cécile
  • Colloids and Surfaces B: Biointerfaces, Vol. 65, Issue 1, p. 140-145
  • DOI: 10.1016/j.colsurfb.2008.03.005

Assembly of large-area, highly ordered, crack-free inverse opal films
journal, May 2010
  • Hatton, B.; Mishchenko, L.; Davis, S.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 23, p. 10354-10359
  • DOI: 10.1073/pnas.1000954107

Proteins in Mesoporous Silicates
journal, October 2008
  • Hudson, Sarah; Cooney, Jakki; Magner, Edmond
  • Angewandte Chemie International Edition, Vol. 47, Issue 45, p. 8582-8594
  • DOI: 10.1002/anie.200705238

Cellular complexity captured in durable silica biocomposites
journal, October 2012
  • Kaehr, B.; Townson, J. L.; Kalinich, R. M.
  • Proceedings of the National Academy of Sciences, Vol. 109, Issue 43, p. 17336-17341
  • DOI: 10.1073/pnas.1205816109

Prescribing diatom morphology: toward genetic engineering of biological nanomaterials
journal, December 2007

Self-Assembly of Highly Phosphorylated Silaffins and Their Function in Biosilica Morphogenesis
journal, October 2002
  • Kröger, Nils; Lorenz, Sonja; Brunner, Eike
  • Science, Vol. 298, Issue 5593, p. 584-586
  • DOI: 10.1126/science.1076221

Species-specific polyamines from diatoms control silica morphology
journal, December 2000
  • Kroger, N.; Deutzmann, R.; Bergsdorf, C.
  • Proceedings of the National Academy of Sciences, Vol. 97, Issue 26, p. 14133-14138
  • DOI: 10.1073/pnas.260496497

Electrostatically Mediated Liposome Fusion and Lipid Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and Delivery
journal, June 2009
  • Liu, Juewen; Jiang, Xingmao; Ashley, Carlee
  • Journal of the American Chemical Society, Vol. 131, Issue 22, p. 7567-7569
  • DOI: 10.1021/ja902039y

Porous Nanoparticle Supported Lipid Bilayers (Protocells) as Delivery Vehicles
journal, February 2009
  • Liu, Juewen; Stace-Naughton, Alison; Jiang, Xingmao
  • Journal of the American Chemical Society, Vol. 131, Issue 4, p. 1354-1355
  • DOI: 10.1021/ja808018y

Diatomaceous Lessons in Nanotechnology and Advanced Materials
journal, August 2009
  • Losic, Dusan; Mitchell, James G.; Voelcker, Nicolas H.
  • Advanced Materials, Vol. 21, Issue 29, p. 2947-2958
  • DOI: 10.1002/adma.200803778

Aerosol-assisted self-assembly of mesostructured spherical nanoparticles
journal, March 1999
  • Lu, Yunfeng; Fan, Hongyou; Stump, Aaron
  • Nature, Vol. 398, Issue 6724, p. 223-226
  • DOI: 10.1038/18410

Synthesis of inorganic materials with complex form
journal, July 1996
  • Mann, Stephen; Ozin, Geoffrey A.
  • Nature, Vol. 382, Issue 6589, p. 313-318
  • DOI: 10.1038/382313a0

Encapsulation of cells within silica matrixes: Towards a new advance in the conception of living hybrid materials
journal, February 2010
  • Meunier, Christophe F.; Dandoy, Philippe; Su, Bao-Lian
  • Journal of Colloid and Interface Science, Vol. 342, Issue 2, p. 211-224
  • DOI: 10.1016/j.jcis.2009.10.050

Infiltration of Silica Inside Fibrillar Collagen
journal, October 2011
  • Niu, Li-na; Jiao, Kai; Qi, Yi-pin
  • Angewandte Chemie International Edition, Vol. 50, Issue 49, p. 11688-11691
  • DOI: 10.1002/anie.201105114

Nanopatterned protein microrings from a diatom that direct silica morphogenesis
journal, February 2011
  • Scheffel, A.; Poulsen, N.; Shian, S.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 8, p. 3175-3180
  • DOI: 10.1073/pnas.1012842108

Organic Templates for the Generation of Inorganic Materials
journal, March 2003
  • van Bommel, Kjeld J. C.; Friggeri, Arianna; Shinkai, Seiji
  • Angewandte Chemie International Edition, Vol. 42, Issue 9, p. 980-999
  • DOI: 10.1002/anie.200390284

Scale-up analysis for a CHO cell culture process in large-scale bioreactors
journal, July 2009
  • Xing, Zizhuo; Kenty, Brian M.; Li, Zheng Jian
  • Biotechnology and Bioengineering, Vol. 103, Issue 4, p. 733-746
  • DOI: 10.1002/bit.22287