Title: Solvent depression of transition temperature to selectively stimulate actuation of shape memory polymer foams

Abstract

An embodiment of the invention is a shape memory polymer (SMP) foam designed to recover its original shape through exposure to a solvent. Thermo-responsive SMPs are polymers designed to maintain a programmed secondary shape until heated above their transition temperature, upon which the polymer recovers its original, or primary, shape. The thermo-responsive SMP foam is programmed to its secondary shape prior to use, typically compression of the foam to a small volume, and remains in this programmed shape until exposed to a selected solvent such as dimethyl sulfoxide or ethyl alcohol. Upon exposure to the solvent, the transition temperature of the SMP foam decreases below the temperature of the environment and the SMP foam actuates to its primary shape. The SMP foam is tailored to actuate upon exposure to specific solvents while minimizing or preventing actuation when exposed to water or other solvents. This selective solvent actuation can be used to increase working time of a SMP foam device, that is, the time allowed for use of a device without undesired actuation, while maintaining functional SMP actuation. Solvent actuated SMP foams can be used in various applications including, but not limited to, treatment of aneurysms and arterio-venous malformations, tissue engineering,more » and wound healing. « less

Inventors:

Boyle, Anthony J.; Hearon, Keith; Maitland, Duncan J.; Nash, Landon D.; Wilson, Thomas S.

Issue Date:

Tue Feb 04 00:00:00 EST 2020

Research Org.:

Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1632506

Patent Number(s):

10548608

Application Number:

15/579,217

Assignee:

Lawrenece Livermore National Security, LLC (Livermore, CA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A61B17/12031 - {complete occlusion}
A61B17/12113 - {within an aneurysm}
A61B17/12181 - {formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices}
A61B17/1219 - {expandable in contact with liquids}
A61B2017/00871 - {polymeric}
A61B2017/00938 - {hydrophobic}
A61B2017/00964 - {composite}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL

A61L2400/16 - Materials with shape-memory or superelastic properties
A61L2430/36 - for embolization or occlusion, e.g. vaso-occlusive compositions or devices
A61L31/06 - obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {
A61L31/14 - Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
A61L31/146 - {Porous materials, e.g. foams or sponges}

C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS

C08L75/04 - Polyurethanes

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DOE Contract Number:  

AC52-07NA27344

Resource Type:

Patent

Resource Relation:

Patent File Date: 06/07/2016

Country of Publication:

United States

Language:

English

Subject:

36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY