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Title: Constructs and systems and methods for engineering a CO2 fixing photorespiratory by-pass pathway

Abstract

Methods and compositions to introduce a synthetic pathway based on the 3-hydroxypropionate bicycle into an organism such as the model cyanobacterium, Synechococcus elongatus sp. PCC 7942. The heterologously expressed pathway acts as a photorespiratory bypass as well as an additional carbon fixation cycle orthogonal to the endogenous Calvin-Benson cycle. We demonstrate the function of all six introduced enzymes, which not only has implications on increasing net-photosynthetic productivity, but also key enzymes in the pathway are involved in high-value products that are of biotechnological interest, such as 3-hydroxypropionate.

Inventors:
; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1600295
Patent Number(s):
10480003
Application Number:
15/230,332
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02P - CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 08/05/2016
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 42 ENGINEERING

Citation Formats

Kerfeld, Cheryl A., Shih, Patrick, Zarzycki, Jan, and Niyogi, Krishna K. Constructs and systems and methods for engineering a CO2 fixing photorespiratory by-pass pathway. United States: N. p., 2019. Web.
Kerfeld, Cheryl A., Shih, Patrick, Zarzycki, Jan, & Niyogi, Krishna K. Constructs and systems and methods for engineering a CO2 fixing photorespiratory by-pass pathway. United States.
Kerfeld, Cheryl A., Shih, Patrick, Zarzycki, Jan, and Niyogi, Krishna K. Tue . "Constructs and systems and methods for engineering a CO2 fixing photorespiratory by-pass pathway". United States. https://www.osti.gov/servlets/purl/1600295.
@article{osti_1600295,
title = {Constructs and systems and methods for engineering a CO2 fixing photorespiratory by-pass pathway},
author = {Kerfeld, Cheryl A. and Shih, Patrick and Zarzycki, Jan and Niyogi, Krishna K.},
abstractNote = {Methods and compositions to introduce a synthetic pathway based on the 3-hydroxypropionate bicycle into an organism such as the model cyanobacterium, Synechococcus elongatus sp. PCC 7942. The heterologously expressed pathway acts as a photorespiratory bypass as well as an additional carbon fixation cycle orthogonal to the endogenous Calvin-Benson cycle. We demonstrate the function of all six introduced enzymes, which not only has implications on increasing net-photosynthetic productivity, but also key enzymes in the pathway are involved in high-value products that are of biotechnological interest, such as 3-hydroxypropionate.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {11}
}

Patent:

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