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Title: Method for implementing non-destructive quality control of substrates and printed biological microarrays

Abstract

A method and apparatus are provided for implementing non-destructive quality control of substrates and printed biological microarrays. A method and apparatus are provided for implementing quality control of gel-based microarrays prepared by dispensing a gel-forming composition on a solid substrate. The method utilizes the difference between the wettability properties of a supporting substrate and a gel, where the gel is hydrophilic. Condensation of vapor of a chemically inert water-soluble liquid, such as water or glycerol, on the surface of a substrate under inspection creates a layer of tiny droplets that affect both transmission and scattering of light on the surface. A pattern of condensation, characterized by spatial distribution, average size of the droplets and spacing between the droplets, reflects variation in wetting properties of the substrate. The pattern of condensation circumscribes printed microarray features to be non-destructively imaged and analyzed.

Inventors:
;
Issue Date:
Research Org.:
U Chicago Argonne LLC, Chicago, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1531603
Patent Number(s):
7598037
Application Number:
11/485,203
Assignee:
U Chicago Argonne LLC (Chicago, IL)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
G - PHYSICS G06 - COMPUTING G06T - IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
DOE Contract Number:  
W-31-109-ENG-38
Resource Type:
Patent
Resource Relation:
Patent File Date: 2006-07-12
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Perov, Alexander N., and Chandler, Darrell P.. Method for implementing non-destructive quality control of substrates and printed biological microarrays. United States: N. p., 2009. Web.
Perov, Alexander N., & Chandler, Darrell P.. Method for implementing non-destructive quality control of substrates and printed biological microarrays. United States.
Perov, Alexander N., and Chandler, Darrell P.. Tue . "Method for implementing non-destructive quality control of substrates and printed biological microarrays". United States. https://www.osti.gov/servlets/purl/1531603.
@article{osti_1531603,
title = {Method for implementing non-destructive quality control of substrates and printed biological microarrays},
author = {Perov, Alexander N. and Chandler, Darrell P.},
abstractNote = {A method and apparatus are provided for implementing non-destructive quality control of substrates and printed biological microarrays. A method and apparatus are provided for implementing quality control of gel-based microarrays prepared by dispensing a gel-forming composition on a solid substrate. The method utilizes the difference between the wettability properties of a supporting substrate and a gel, where the gel is hydrophilic. Condensation of vapor of a chemically inert water-soluble liquid, such as water or glycerol, on the surface of a substrate under inspection creates a layer of tiny droplets that affect both transmission and scattering of light on the surface. A pattern of condensation, characterized by spatial distribution, average size of the droplets and spacing between the droplets, reflects variation in wetting properties of the substrate. The pattern of condensation circumscribes printed microarray features to be non-destructively imaged and analyzed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {10}
}

Works referenced in this record:

Impact of surface chemistry and blocking strategies on DNA microarrays
journal, August 2003


Methods of determining a quality of an array substrate
patent-application, October 2005


Methods for producing multilayer ligand arrays
patent-application, April 2004


Clinically intelligent diagnostic devices and mehtods
patent-application, July 2002