Detection of electrophilic and nucleophilic chemical agents
Abstract
A "real time" method for detecting chemical agents generally and particularly electrophilic and nucleophilic species by employing tunable, precursor sensor materials that mimic the physiological interaction of these agents to form highly florescent berberine-type alkaloids that can be easily and rapidly detected. These novel precursor sensor materials can be tuned for reaction with both electrophilic (chemical species, toxins) and nucleophilic (proteins and other biological molecules) species. By bonding or otherwise attaching these precursor molecules to a surface or substrate they can be used in numerous applications.
- Inventors:
- Issue Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1150085
- Patent Number(s):
- 8802444
- Application Number:
- 13/553,959
- Assignee:
- Sandia Corporation (Albuquerque, NM)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
Citation Formats
McElhanon, James R., and Shepodd, Timothy J. Detection of electrophilic and nucleophilic chemical agents. United States: N. p., 2014.
Web.
McElhanon, James R., & Shepodd, Timothy J. Detection of electrophilic and nucleophilic chemical agents. United States.
McElhanon, James R., and Shepodd, Timothy J. Tue .
"Detection of electrophilic and nucleophilic chemical agents". United States. https://www.osti.gov/servlets/purl/1150085.
@article{osti_1150085,
title = {Detection of electrophilic and nucleophilic chemical agents},
author = {McElhanon, James R. and Shepodd, Timothy J.},
abstractNote = {A "real time" method for detecting chemical agents generally and particularly electrophilic and nucleophilic species by employing tunable, precursor sensor materials that mimic the physiological interaction of these agents to form highly florescent berberine-type alkaloids that can be easily and rapidly detected. These novel precursor sensor materials can be tuned for reaction with both electrophilic (chemical species, toxins) and nucleophilic (proteins and other biological molecules) species. By bonding or otherwise attaching these precursor molecules to a surface or substrate they can be used in numerous applications.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {8}
}
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Works referenced in this record:
Oxidation Reactions of 2′-Functionalized 3-Aryltetrahydro and 3,4-Dihydroisoquinolines
journal, November 1995
- Sotomayor, Nuria; Domínguez, Esther; Lete, Esther
- Tetrahedron, Vol. 51, Issue 46