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Title: Detection of Electrophilic and Nucleophilic Chemical Agents

Abstract

A "real time" method for detecting electrophilic and nucleophilic species generally by employing tunable, precursor sensor materials that mimic the physiological interaction of these agents to form highly florescent berberine-type alkaloids that can be easily and rapidly detected. These novel precursor sensor materials can be tuned for reaction with both electrophilic (chemical species, toxins) and nucleophilic (proteins and other biological molecules) species.

Inventors:
 [1];  [2]
  1. Manteca, CA
  2. Livermore, CA
Issue Date:
Research Org.:
Sandia National Lab. (SNL-CA), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
953735
Patent Number(s):
7449579
Application Number:
Assignee:
Sandia Corporation (Livermore, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

McElhanon, James R, and Shepodd, Timothy J. Detection of Electrophilic and Nucleophilic Chemical Agents. United States: N. p., 2008. Web.
McElhanon, James R, & Shepodd, Timothy J. Detection of Electrophilic and Nucleophilic Chemical Agents. United States.
McElhanon, James R, and Shepodd, Timothy J. Tue . "Detection of Electrophilic and Nucleophilic Chemical Agents". United States. https://www.osti.gov/servlets/purl/953735.
@article{osti_953735,
title = {Detection of Electrophilic and Nucleophilic Chemical Agents},
author = {McElhanon, James R and Shepodd, Timothy J},
abstractNote = {A "real time" method for detecting electrophilic and nucleophilic species generally by employing tunable, precursor sensor materials that mimic the physiological interaction of these agents to form highly florescent berberine-type alkaloids that can be easily and rapidly detected. These novel precursor sensor materials can be tuned for reaction with both electrophilic (chemical species, toxins) and nucleophilic (proteins and other biological molecules) species.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {11}
}

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Works referenced in this record:

The fluorescence properties of protoberberine and tetrahydroprotoberberine alkaloids
journal, January 1976