System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures
Abstract
An ATR-FTIR device and system are described that defect live-cell responses to stimuli and perturbations in real-time. The system and device can monitor perturbations resulting from exposures to various physical, chemical, and biological materials in real-time, as well as those sustained over a long period of time, including those associated with stimuli having unknown modes-of-action (e.g. nanoparticles). The device and system can also be used to identify specific chemical species or substances that profile cellular responses to these perturbations.
- Inventors:
-
- Richland, WA
- West Richland, WA
- Benton City, WA
- Issue Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1019120
- Patent Number(s):
- 7956328
- Application Number:
- US Patent Application 12/511,833
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC05-76RLO1830
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Sundaram, S Kamakshi, Riley, Brian J, Weber, Thomas J, Sacksteder, Colette A, and Addleman, R Shane. System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures. United States: N. p., 2011.
Web.
Sundaram, S Kamakshi, Riley, Brian J, Weber, Thomas J, Sacksteder, Colette A, & Addleman, R Shane. System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures. United States.
Sundaram, S Kamakshi, Riley, Brian J, Weber, Thomas J, Sacksteder, Colette A, and Addleman, R Shane. Tue .
"System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures". United States. https://www.osti.gov/servlets/purl/1019120.
@article{osti_1019120,
title = {System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures},
author = {Sundaram, S Kamakshi and Riley, Brian J and Weber, Thomas J and Sacksteder, Colette A and Addleman, R Shane},
abstractNote = {An ATR-FTIR device and system are described that defect live-cell responses to stimuli and perturbations in real-time. The system and device can monitor perturbations resulting from exposures to various physical, chemical, and biological materials in real-time, as well as those sustained over a long period of time, including those associated with stimuli having unknown modes-of-action (e.g. nanoparticles). The device and system can also be used to identify specific chemical species or substances that profile cellular responses to these perturbations.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {6}
}
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