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Title: System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures

Abstract

An ATR-FTIR device and system are described that defect live-cell responses to stimuli and perturbations in real-time. The system and device can monitor perturbations resulting from exposures to various physical, chemical, and biological materials in real-time, as well as those sustained over a long period of time, including those associated with stimuli having unknown modes-of-action (e.g. nanoparticles). The device and system can also be used to identify specific chemical species or substances that profile cellular responses to these perturbations.

Inventors:
 [1];  [2];  [1];  [2];  [3]
  1. Richland, WA
  2. West Richland, WA
  3. Benton City, WA
Issue Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1019120
Patent Number(s):
7956328
Application Number:
US Patent Application 12/511,833
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC05-76RLO1830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Sundaram, S Kamakshi, Riley, Brian J, Weber, Thomas J, Sacksteder, Colette A, and Addleman, R Shane. System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures. United States: N. p., 2011. Web.
Sundaram, S Kamakshi, Riley, Brian J, Weber, Thomas J, Sacksteder, Colette A, & Addleman, R Shane. System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures. United States.
Sundaram, S Kamakshi, Riley, Brian J, Weber, Thomas J, Sacksteder, Colette A, and Addleman, R Shane. Tue . "System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures". United States. https://www.osti.gov/servlets/purl/1019120.
@article{osti_1019120,
title = {System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures},
author = {Sundaram, S Kamakshi and Riley, Brian J and Weber, Thomas J and Sacksteder, Colette A and Addleman, R Shane},
abstractNote = {An ATR-FTIR device and system are described that defect live-cell responses to stimuli and perturbations in real-time. The system and device can monitor perturbations resulting from exposures to various physical, chemical, and biological materials in real-time, as well as those sustained over a long period of time, including those associated with stimuli having unknown modes-of-action (e.g. nanoparticles). The device and system can also be used to identify specific chemical species or substances that profile cellular responses to these perturbations.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {6}
}

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Works referenced in this record:

A technique for monitoring mammalian cell growth and inhibition in situ via Fourier transform infrared spectroscopy
journal, November 1988


In situ observation of a cell adhesion and metabolism using surface infrared spectroscopy
journal, November 2007


Quantitative and simultaneous detection of four foodborne bacterial pathogens with a multi-channel SPR sensor
journal, December 2006