skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Method of assessing a lipid-related health risk based on ion mobility analysis of lipoproteins

Abstract

A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.

Inventors:
 [1];  [2];  [2]
  1. Danville, CA
  2. Berkeley, CA
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1010277
Patent Number(s):
7851224
Application Number:
12/775,225
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Benner, W Henry, Krauss, Ronald M, and Blanche, Patricia J. Method of assessing a lipid-related health risk based on ion mobility analysis of lipoproteins. United States: N. p., 2010. Web.
Benner, W Henry, Krauss, Ronald M, & Blanche, Patricia J. Method of assessing a lipid-related health risk based on ion mobility analysis of lipoproteins. United States.
Benner, W Henry, Krauss, Ronald M, and Blanche, Patricia J. Tue . "Method of assessing a lipid-related health risk based on ion mobility analysis of lipoproteins". United States. https://www.osti.gov/servlets/purl/1010277.
@article{osti_1010277,
title = {Method of assessing a lipid-related health risk based on ion mobility analysis of lipoproteins},
author = {Benner, W Henry and Krauss, Ronald M and Blanche, Patricia J},
abstractNote = {A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {12}
}

Patent:

Save / Share:

Works referenced in this record:

Intermediate-Density Lipoproteins and Progression of Carotid Arterial Wall Intima-Media Thickness
journal, April 1997


Intrinsic Size Parameters for Val, Ile, Leu, Gln, Thr, Phe, and Trp Residues from Ion Mobility Measurements of Polyamino Acid Ions
journal, October 1999


Associations of age, adiposity, alcohol intake, menstrual status, and estrogen therapy with high-density lipoprotein subclasses.
journal, November 1993


Persistence of Low HDL-C Levels After Weight Reduction in Older Men With Small LDL Particles
journal, March 1995


Is the Size of Low-Density Lipoprotein Particles Related to the Risk of Coronary Heart Disease?
journal, February 2002


A very-low-fat diet is not associated with improved lipoprotein profiles in men with a predominance of large, low-density lipoproteins
journal, March 1999


Low‐density lipoprotein subclass patterns and lipoprotein response to a reduced‐fat diet in men
journal, January 1994


Diet-gene interactions in human lipoprotein metabolism.
journal, August 1997


Low-density-lipoprotein subclasses and response to a low-fat diet in healthy men
journal, August 1995


Variability of Plasma HDL Subclass Concentrations in Men and Women Over Time
journal, April 1997


Association of small low-density lipoprotein particles with the incidence of coronary artery disease in men and women
journal, September 1996


Reduced LDL particle size in children consuming a very-low-fat diet is related to parental LDL-subclass patterns
journal, June 2000


D IETARY AND G ENETIC E FFECTS ON L OW -D ENSITY L IPOPROTEIN H ETEROGENEITY
journal, July 2001


Lipoprotein Subclasses in the Monitored Atherosclerosis Regression Study (MARS): Treatment Effects and Relation to Coronary Angiographic Progression
journal, May 1996


LDL Subclass Patterns and Lipoprotein Response to a Low-Fat, High-Carbohydrate Diet in Women
journal, April 1997


Atherogenic Lipoprotein Phenotype and Diet-Gene Interactions
journal, February 2001


Change in dietary saturated fat intake is correlated with change in mass of large low-density-lipoprotein particles in men
journal, May 1998


Genetic underpinnings of LDL size and density: a role for hepatic lipase?
journal, June 2000


Analysis and quantitation of biotinylated apoB-containing lipoproteins with streptavidin-Cy3
journal, July 2002


Charge‐reduced nano electrospray ionization combined with differential mobility analysis of peptides, proteins, glycoproteins, noncovalent protein complexes and viruses
journal, September 2001

  • Bacher, Gerold; Szymanski, Wladyslaw W.; Kaufman, Stanley L.
  • Journal of Mass Spectrometry, Vol. 36, Issue 9, p. 1038-1052
  • https://doi.org/10.1002/jms.208

Capillary electrophoresis-electrospray ionization-mass spectrometry
journal, July 1989


Influence of ApoE Content on Receptor Binding of Large, Buoyant LDL in Subjects With Different LDL Subclass Phenotypes
journal, March 1998


Detection and quantitation of LDL subfractions
journal, January 1992


Enhanced oxidative susceptibility and reduced antioxidant content of metabolic precursors of small, dense low-density lipoproteins
journal, February 2001


Low-fat diets, lipoprotein subclasses, and heart disease risk
journal, December 1999


Effect of fluvastatin on low-density lipoprotein peak particle diameter
journal, July 1997


Metabolic origins and clinical significance of LDL heterogeneity
journal, September 2002


A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction
journal, September 1996


Relation of LDL Size to the Insulin Resistance Syndrome and Coronary Heart Disease in American Indians: The Strong Heart Study
journal, November 1997


Lipoprotein subclasses in genetic studies: The Berkeley data set: Lipoprotein Subclasses in Genetic Analysis
journal, January 1993


Predominance of Large LDL and Reduced HDL 2 Cholesterol in Normolipidemic Men With Coronary Artery Disease
journal, August 1995