skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Ion mobility analysis of lipoproteins

Patent ·
OSTI ID:913426
 [1];  [2];  [2]
  1. Danville, CA
  2. Berkeley, CA
+ Show Author Affiliations

A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC03-76SF00098
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
7,259,018
Application Number:
10/293,610
OSTI ID:
913426
Country of Publication:
United States
Language:
English

References (26)

Intermediate-Density Lipoproteins and Progression of Carotid Arterial Wall Intima-Media Thickness journal April 1997
Intrinsic Size Parameters for Val, Ile, Leu, Gln, Thr, Phe, and Trp Residues from Ion Mobility Measurements of Polyamino Acid Ions journal October 1999
Associations of age, adiposity, alcohol intake, menstrual status, and estrogen therapy with high-density lipoprotein subclasses. journal November 1993
Persistence of Low HDL-C Levels After Weight Reduction in Older Men With Small LDL Particles journal March 1995
Association of lipoprotein subclass distribution with use of selective and non-selective beta-blocker medications in patients with coronary heart disease journal June 1993
Low‐density lipoprotein subclass patterns and lipoprotein response to a reduced‐fat diet in men journal January 1994
The associations of high-density lipoprotein subclasses with insulin and glucose levels, physical activity, resting heart rate, and regional adiposity in men with coronary artery disease: The stanford coronary risk intervention project baseline survey journal January 1995
Diet-gene interactions in human lipoprotein metabolism. journal August 1997
Low-density-lipoprotein subclasses and response to a low-fat diet in healthy men journal August 1995
Variability of Plasma HDL Subclass Concentrations in Men and Women Over Time journal April 1997
Effects of dietary fat on high-density-lipoprotein subclasses are influenced by both apolipoprotein E isoforms and low-density-lipoprotein subclass patterns journal June 1995
Association of small low-density lipoprotein particles with the incidence of coronary artery disease in men and women journal September 1996
Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease. The Stanford Coronary Risk Intervention Project (SCRIP). journal March 1994
Lipoprotein Subclasses in the Monitored Atherosclerosis Regression Study (MARS): Treatment Effects and Relation to Coronary Angiographic Progression journal May 1996
LDL Subclass Patterns and Lipoprotein Response to a Low-Fat, High-Carbohydrate Diet in Women journal April 1997
The hypertriglyceridemia of acquired immunodeficiency syndrome is associated with an increased prevalence of low density lipoprotein subclass pattern B journal June 1993
Change in dietary saturated fat intake is correlated with change in mass of large low-density-lipoprotein particles in men journal May 1998
Charge‐reduced nano electrospray ionization combined with differential mobility analysis of peptides, proteins, glycoproteins, noncovalent protein complexes and viruses
  • Bacher, Gerold; Szymanski, Wladyslaw W.; Kaufman, Stanley L.
  • Journal of Mass Spectrometry, Vol. 36, Issue 9, p. 1038-1052 https://doi.org/10.1002/jms.208
journal September 2001
Capillary electrophoresis-electrospray ionization-mass spectrometry journal July 1989
Influence of ApoE Content on Receptor Binding of Large, Buoyant LDL in Subjects With Different LDL Subclass Phenotypes journal March 1998
Detection and quantitation of LDL subfractions journal January 1992
Effect of fluvastatin on low-density lipoprotein peak particle diameter journal July 1997
A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction journal September 1996
Relation of LDL Size to the Insulin Resistance Syndrome and Coronary Heart Disease in American Indians: The Strong Heart Study journal November 1997
Lipoprotein subclasses in genetic studies: The Berkeley data set: Lipoprotein Subclasses in Genetic Analysis journal January 1993
Predominance of Large LDL and Reduced HDL 2 Cholesterol in Normolipidemic Men With Coronary Artery Disease journal August 1995

Similar Records

Related Subjects

59 BASIC BIOLOGICAL SCIENCES