Sabin-to-Mahoney Transition Model of Quasispecies Replication
Qspp is an agent-based stochastic simulation model of the Poliovirus Sabin-to-Mahoney transition. This code simulates a cell-to-cell model of Poliovirus replication. The model tracks genotypes (virus genomes) as they are replicated in cells, and as the cells burst and release particles into the medium of a culture dish. An inoculum is then taken from the pool of virions and is used to inoculate cells on a new dish. This process repeats. The Sabin genotype comprises the initial inoculum. Nucleotide positions that match the Sabin1 (vaccine strain) and Mahoney (wild type) genotypes, as well as the neurovirulent phenotype (from the literature) are enumerated as constants.
- Short Name / Acronym:
- QSPP
- Site Accession Number:
- 5526
- Software Type:
- Scientific
- License(s):
- GNU General Public License v2.0
- Research Organization:
- Lawrence Livermore National Laboratory
- Sponsoring Organization:
- USDOEPrimary Award/Contract Number:AC52-07NA27344
- DOE Contract Number:
- AC52-07NA27344
- Code ID:
- 3304
- OSTI ID:
- code-3304
- Country of Origin:
- United States
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