Neural assembly models derived through nano-scale measurements.
This report summarizes accomplishments of a three-year project focused on developing technical capabilities for measuring and modeling neuronal processes at the nanoscale. It was successfully demonstrated that nanoprobes could be engineered that were biocompatible, and could be biofunctionalized, that responded within the range of voltages typically associated with a neuronal action potential. Furthermore, the Xyce parallel circuit simulator was employed and models incorporated for simulating the ion channel and cable properties of neuronal membranes. The ultimate objective of the project had been to employ nanoprobes in vivo, with the nematode C elegans, and derive a simulation based on the resulting data. Techniques were developed allowing the nanoprobes to be injected into the nematode and the neuronal response recorded. To the authors's knowledge, this is the first occasion in which nanoparticles have been successfully employed as probes for recording neuronal response in an in vivo animal experimental protocol.
- Research Organization:
- Sandia National Laboratories
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC04-94AL85000
- OSTI ID:
- 993899
- Report Number(s):
- SAND2009-6209
- Country of Publication:
- United States
- Language:
- English
Similar Records
Simulating neural systems with Xyce.
Toxicological assessment of mesoporous silica particles in the nematode Caenorhabditis elegans
Technical Report
·
Fri Nov 30 23:00:00 EST 2012
·
OSTI ID:1096952
Toxicological assessment of mesoporous silica particles in the nematode Caenorhabditis elegans
Journal Article
·
Mon Oct 15 00:00:00 EDT 2018
· Environmental Research
·
OSTI ID:23107954