Premature centromere division: A possible manifestation of chromosome instability
Journal Article
·
· American Journal of Medical Genetics
- Univ. Medical School, Pecs (Hungary)
- Univ. of Children`s Hospital, Basle (Switzerland)
Retrospective analysis of {open_quotes}routine{close_quotes} chromosome preparations from 2 patients with Fanconi anemia and 2 others with ataxia-teleangiectasia showed increased chromosome breakage and a tendency to premature centromere division (PCD) with special reference to early separation of the large acrocentric (13-15) chromosomes. The findings suggest that PCD may be a manifestation of chromosome instability related to potential malignancy. 28 refs., 1 fig., 1 tab.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 99075
- Journal Information:
- American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 1 Vol. 56; ISSN 0148-7299; ISSN AJMGDA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Premature centromere division and other centromeric misbehavior
Chromosome instability syndromes
Nature and distribution of chromosomal intertwinings in Saccharomyces cerevisiae
Conference
·
Thu Dec 30 23:00:00 EST 1993
·
OSTI ID:28433
Chromosome instability syndromes
Book
·
Thu Dec 30 23:00:00 EST 1993
·
OSTI ID:56695
Nature and distribution of chromosomal intertwinings in Saccharomyces cerevisiae
Journal Article
·
Mon Jan 31 23:00:00 EST 1994
· Molecular and Cellular Biology
·
OSTI ID:577153