Thermodynamic functions and intraparticle mass transfer kinetics of structural analogues of a template on molecularly imprinted polymers in liquid chromatography
- University of Tennessee, Knoxville (UTK)
- ORNL
The parameters of the thermodynamics and mass transfer kinetics of the structural analogues (L-enantiomers) of the template were measured on an Fmoc-L-tryptophan (Fmoc-L-Trp) imprinted polymer, at different temperatures. The equilibrium isotherm data and the overloaded band profiles of these compounds were measured at temperatures of 298, 313, 323, and 333 K. The isotherm data were modeled. The thermodynamic functions of the different adsorption sites were derived from the isotherm parameters, using van't Hoff plots. The mass transfer parameters were derived by comparing the experimental peak profiles and profiles calculated using the lumped pore diffusion (POR) model for chromatography. These data show that (1) the strength between the substrate molecules and the MIP increases with increasing number of functional groups on the substrates; (2) enthalpy is the driving force for the affinity of the substrates for the MIP; (3) surface diffusion is the dominant mass transfer mechanism of the substrates through the porous MIP. For those substrate molecules that have the same stereochemistry as the template, the energetic surface heterogeneity needs to be incorporated into the surface diffusion coefficients. Heterogeneous surface diffusivities decrease with increasing affinity of the substrates for the MIP.
- Research Organization:
- Oak Ridge National Laboratory (ORNL)
- Sponsoring Organization:
- SC USDOE - Office of Science (SC)
- DOE Contract Number:
- AC05-00OR22725
- OSTI ID:
- 989573
- Journal Information:
- Journal of Chromatography A, Journal Name: Journal of Chromatography A Journal Issue: 2005 Vol. 1097; ISSN 0021-9673
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ADSORPTION
ADSORPTION ISOTHERMS
DIFFUSION
ENTHALPY
Fmoc-L-tryptophan imprinted polymers
KINETICS
LIQUID COLUMN CHROMATOGRAPHY
MASS TRANSFER
POLYMERS
POR model
STEREOCHEMISTRY
THERMODYNAMICS
enthalpy
entropy
frontal analysis
isoteric heat of adsorption
isotherm parameters
surface diffusion
van't Hoff plot