skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Squid detected NMR and MRI at ultralow fields

Abstract

Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned dc superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.

Inventors:
 [1];  [1];  [2];  [3]
  1. Berkeley, CA
  2. Monona, WI
  3. London, GB
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
985708
Patent Number(s):
7,466,132
Application Number:
11/740,339
Assignee:
LBNL
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Clarke, John, Pines, Alexander, McDermott, Robert F, and Trabesinger, Andreas H. Squid detected NMR and MRI at ultralow fields. United States: N. p., 2008. Web.
Clarke, John, Pines, Alexander, McDermott, Robert F, & Trabesinger, Andreas H. Squid detected NMR and MRI at ultralow fields. United States.
Clarke, John, Pines, Alexander, McDermott, Robert F, and Trabesinger, Andreas H. 2008. "Squid detected NMR and MRI at ultralow fields". United States. https://www.osti.gov/servlets/purl/985708.
@article{osti_985708,
title = {Squid detected NMR and MRI at ultralow fields},
author = {Clarke, John and Pines, Alexander and McDermott, Robert F and Trabesinger, Andreas H},
abstractNote = {Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned dc superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.},
doi = {},
url = {https://www.osti.gov/biblio/985708}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {12}
}

Works referenced in this record:

High Tc superconducting asymmetric gradiometer for biomagnetic applications
journal, July 2000


Low field magnetic resonance images of polarized noble gases obtained with a dc superconducting quantum interference device
journal, April 1998


Using a magnetometer to image a two‐dimensional current distribution
journal, January 1989


Variable sample temperature scanning superconducting quantum interference device microscope
journal, June 1999


High-T/sub c/ SQUIDs for low-field NMR and MRI of room temperature samples
journal, June 1999


Direct detection of low‐frequency NMR using a dc SQUID
journal, March 1986


High-Tc super conducting quantum interference devices with slots or holes: Low 1/f noise in ambient magnetic fields
journal, April 1997


Nuclear magnetism of liquid systems in the earth field range
journal, February 1980


SQUID detected NMR and NQR
journal, March 1998


Microstrip superconducting quantum interference device radio-frequency amplifier: Tuning and cascading
journal, November 1999


Microtesla MRI with a superconducting quantum interference device
journal, May 2004


Low‐temperature nuclear magnetic resonance with a dc SQUID amplifier
journal, January 1986


NMR imaging in the earth's magnetic field
journal, September 1990


Detection of 14N and 35Cl in Cocaine Base and Hydrochloride Using NQR, NMR, and SQUID Techniques
journal, July 1995


In vivo magnetic resonance vascular imaging using laser-polarized 3He microbubbles
journal, September 1998


Superconducting quantum interference device as a near-quantum-limited amplifier at 0.5 GHz
journal, February 2001


SQUID detected NMR of laser-polarized xenon at 4.2 K and at frequencies down to 200 Hz
journal, June 1997


NMR and MRI obtained with high transition temperature dc SQUIDs
journal, January 1999


A 4.2 K receiver coil and SQUID amplifier used to improve the SNR of low-field magnetic resonance images of the human arm
journal, February 1997


Low-field magnetic resonance imaging with a high-Tc dc superconducting quantum interference device
journal, December 1999


Superconducting analogue electronics for research and industry
journal, November 2003


CHEMISTRY: Whisper of Magnetism Tells Molecules Apart
journal, March 2002


SQUIDs for nondestructive evaluation
journal, February 1997


Isotropic proton-detected local-field nuclear magnetic resonance in solids
journal, February 2005


Nitrogen-14 SQUID NQR of L-Ala-L-His and of Serine
journal, December 1994


Ultrasensitive magnetic biosensor for homogeneous immunoassay
journal, December 2000


Transient Nuclear Induction Signals Associated with Pure Quadrupole Interactions
journal, February 1954


Nuclear magnetic resonance using a high temperature superconducting quantum interference device
journal, February 1997


Application of superconducting quantum interference devices to nuclear magnetic resonance
journal, January 1998


The superconducting quantum interference device microstrip amplifier: Computer models
journal, December 2000


Detection of bacteria in suspension by using a superconducting quantum interference device
journal, December 2003


Whole cortex, 64 channel SQUID biomagnetometer system
journal, March 1993


Relaxation-Time Measurement and Imaging in the Earth′s Magnetic-Field
journal, October 1994


Erdfeld-NMR: Apparative Entwicklungen zur In-vivo-Analyse von Körperflüssigkeiten und weichem Gewebe
journal, January 1999


Three-dimensional phase-encoded chemical shift MRI in the presence of inhomogeneous fields
journal, June 2004


Novel approaches to low-cost MRI
journal, August 1993


Flux-bias stabilization scheme for a radio-frequency amplifier based on a superconducting quantum interference device
journal, September 2001


Dynamic nuclear polarization at very low magnetic fields
journal, July 1998


Development of a Functionalized Xenon Biosensor
journal, November 2004


Broadband SQUID NMR with Room-Temperature Samples
journal, June 1995


Radio-frequency amplifier with tenth-kelvin noise temperature based on a microstrip direct current superconducting quantum interference device
journal, August 1999


Low readout field magnetic resonance imaging of hyperpolarized xenon and water in a single system
journal, March 2002


Radio-frequency amplifier based on a niobium dc superconducting quantum interference device with microstrip input coupling
journal, June 1998