Squid detected NMR and MRI at ultralow fields

Clarke, John; Pines, Alexander; McDermott, Robert F; Trabesinger, Andreas H

Title: Squid detected NMR and MRI at ultralow fields

Patent · Tue Dec 16 00:00:00 EST 2008

OSTI ID:985708

Clarke, John ^[1]; Pines, Alexander ^[1]; McDermott, Robert F ^[2]; Trabesinger, Andreas H ^[3]

Berkeley, CA
Monona, WI
London, GB

Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned dc superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.

View Patent

Cite

Export

Save

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: LBNL

Patent Number(s):: 7,466,132

Application Number:: 11/740,339

OSTI ID:: 985708

Country of Publication:: United States

Language:: English

References (49)

High Tc superconducting asymmetric gradiometer for biomagnetic applications Kouznetsov, K. A.; Borgmann, J.; Clarke, John Review of Scientific Instruments, Vol. 71, Issue 7 https://doi.org/10.1063/1.1150706	journal	July 2000
Low field magnetic resonance images of polarized noble gases obtained with a dc superconducting quantum interference device Augustine, Matthew P.; Wong-Foy, Annjoe; Yarger, Jeffery L. Applied Physics Letters, Vol. 72, Issue 15 https://doi.org/10.1063/1.121223	journal	April 1998
Using a magnetometer to image a two‐dimensional current distribution Roth, Bradley J.; Sepulveda, Nestor G.; Wikswo, John P. Journal of Applied Physics, Vol. 65, Issue 1 https://doi.org/10.1063/1.342549	journal	January 1989
Variable sample temperature scanning superconducting quantum interference device microscope Kirtley, J. R.; Tsuei, C. C.; Moler, K. A. Applied Physics Letters, Vol. 74, Issue 26 https://doi.org/10.1063/1.123244	journal	June 1999
High-T/sub c/ SQUIDs for low-field NMR and MRI of room temperature samples Schlenga, K.; McDermott, R. F.; Clarke, J. IEEE Transactions on Appiled Superconductivity, Vol. 9, Issue 2 https://doi.org/10.1109/77.784006	journal	June 1999
Direct detection of low‐frequency NMR using a dc SQUID Friedman, L. J.; Wennberg, A. K. M.; Ytterboe, S. N. Review of Scientific Instruments, Vol. 57, Issue 3 https://doi.org/10.1063/1.1138900	journal	March 1986
High-Tc super conducting quantum interference devices with slots or holes: Low 1/f noise in ambient magnetic fields Dantsker, E.; Tanaka, S.; Clarke, John Applied Physics Letters, Vol. 70, Issue 15 https://doi.org/10.1063/1.118776	journal	April 1997
Nuclear magnetism of liquid systems in the earth field range Béné, Georges J. Physics Reports, Vol. 58, Issue 4 https://doi.org/10.1016/0370-1573(80)90012-5	journal	February 1980
SQUID detected NMR and NQR Augustine, Matthew P.; TonThat, Dinh M.; Clarke, John Solid State Nuclear Magnetic Resonance, Vol. 11, Issue 1-2 https://doi.org/10.1016/S0926-2040(97)00103-3	journal	March 1998
Harmonic distortion and intermodulation products in the microstrip amplifier based on a superconducting quantum interference device Mück, Michael; Clarke, John Applied Physics Letters, Vol. 78, Issue 23 https://doi.org/10.1063/1.1377043	journal	June 2001
In situ identification of human physiological fluids by nuclear magnetism in the Earth’s field Bene, G. -J.; Borcard, B.; Hiltbrand, E. Philosophical Transactions of the Royal Society of London. B, Biological Sciences, Vol. 289, Issue 1037, p. 501-502 https://doi.org/10.1098/rstb.1980.0068	journal	June 1980
Microstrip superconducting quantum interference device radio-frequency amplifier: Tuning and cascading Mück, Michael; André, Marc-Olivier; Clarke, John Applied Physics Letters, Vol. 75, Issue 22 https://doi.org/10.1063/1.125383	journal	November 1999
Microtesla MRI with a superconducting quantum interference device McDermott, R.; Lee, S.; Haken, B. t. Proceedings of the National Academy of Sciences, Vol. 101, Issue 21 https://doi.org/10.1073/pnas.0402382101	journal	May 2004
Low‐temperature nuclear magnetic resonance with a dc SQUID amplifier Freeman, M. R.; Germain, R. S.; Richardson, R. C. Applied Physics Letters, Vol. 48, Issue 4 https://doi.org/10.1063/1.96587	journal	January 1986
NMR imaging in the earth's magnetic field Stepišnik, J.; Eržen, V.; Kos, M. Magnetic Resonance in Medicine, Vol. 15, Issue 3 https://doi.org/10.1002/mrm.1910150305	journal	September 1990
Detection of 14N and 35Cl in Cocaine Base and Hydrochloride Using NQR, NMR, and SQUID Techniques Yesinowski, James P.; Buess, Michael L.; Garroway, Allen N. Analytical Chemistry, Vol. 67, Issue 13 https://doi.org/10.1021/ac00109a053	journal	July 1995
Direct current superconducting quantum interference device spectrometer for pulsed nuclear magnetic resonance and nuclear quadrupole resonance at frequencies up to 5 MHz TonThat, Dinh M.; Clarke, John Review of Scientific Instruments, Vol. 67, Issue 8 https://doi.org/10.1063/1.1147122	journal	August 1996
In vivo magnetic resonance vascular imaging using laser-polarized 3He microbubbles Chawla, M. S.; Chen, X. J.; Moller, H. E. Proceedings of the National Academy of Sciences, Vol. 95, Issue 18 https://doi.org/10.1073/pnas.95.18.10832	journal	September 1998
Nuclear spin relaxation in liquids and gases Webb, G. A.; Ludwig, R. Nuclear Magnetic Resonance https://doi.org/10.1039/9781847553881-00201	book	May 2003
Superconducting quantum interference device as a near-quantum-limited amplifier at 0.5 GHz Mück, Michael; Kycia, J. B.; Clarke, John Applied Physics Letters, Vol. 78, Issue 7 https://doi.org/10.1063/1.1347384	journal	February 2001
SQUID detected NMR of laser-polarized xenon at 4.2 K and at frequencies down to 200 Hz TonThat, Dinh M.; Ziegeweid, M.; Song, Y. -Q. Chemical Physics Letters, Vol. 272, Issue 3-4 https://doi.org/10.1016/S0009-2614(97)88016-5	journal	June 1997
NMR and MRI obtained with high transition temperature dc SQUIDs Souza, R. E. de; Schlenga, K.; Wong-Foy, A. Journal of the Brazilian Chemical Society, Vol. 10, Issue 4 https://doi.org/10.1590/S0103-50531999000400009	journal	January 1999
A 4.2 K receiver coil and SQUID amplifier used to improve the SNR of low-field magnetic resonance images of the human arm Seton, H. C.; Hutchison, J. M. S.; Bussell, D. M. Measurement Science and Technology, Vol. 8, Issue 2 https://doi.org/10.1088/0957-0233/8/2/015	journal	February 1997
Low-field magnetic resonance imaging with a high-Tc dc superconducting quantum interference device Schlenga, K.; McDermott, R.; Clarke, John Applied Physics Letters, Vol. 75, Issue 23 https://doi.org/10.1063/1.125432	journal	December 1999
Superconducting analogue electronics for research and industry Winkler, D. Superconductor Science and Technology, Vol. 16, Issue 12 https://doi.org/10.1088/0953-2048/16/12/056	journal	November 2003
Proposal For An Improvement Of NMR-Imaging By Low-Temperature-squid- Detection Towards Molecular Kinetic Measurements Localized To A Small Sub-Region Of The Sample Bergmann, W. H. Biomagnetism https://doi.org/10.1515/9783110863529-042	book	December 1981
CHEMISTRY: Whisper of Magnetism Tells Molecules Apart Service, R. F. Science, Vol. 295, Issue 5563 https://doi.org/10.1126/science.295.5563.2195a	journal	March 2002
SQUIDs for nondestructive evaluation Jenks, W. G.; Sadeghi, S. S. H.; Wikswo, J. P. Journal of Physics D: Applied Physics, Vol. 30, Issue 3 https://doi.org/10.1088/0022-3727/30/3/002	journal	February 1997
Isotropic proton-detected local-field nuclear magnetic resonance in solids Havlin, Robert H.; Walls, Jamie D.; Pines, Alexander The Journal of Chemical Physics, Vol. 122, Issue 7 https://doi.org/10.1063/1.1844296	journal	February 2005
Nitrogen-14 SQUID NQR of L-Ala-L-His and of Serine Werner-Zwanziger, Ulrike; Ziegeweid, Marcia; Black, Bruce Zeitschrift für Naturforschung A, Vol. 49, Issue 12 https://doi.org/10.1515/zna-1994-1213	journal	December 1994
Ultrasensitive magnetic biosensor for homogeneous immunoassay Chemla, Y. R.; Grossman, H. L.; Poon, Y. Proceedings of the National Academy of Sciences, Vol. 97, Issue 26 https://doi.org/10.1073/pnas.97.26.14268	journal	December 2000
Transient Nuclear Induction Signals Associated with Pure Quadrupole Interactions Bloom, M.; Norberg, R. E. Physical Review, Vol. 93, Issue 3 https://doi.org/10.1103/PhysRev.93.638	journal	February 1954
Nuclear magnetic resonance using a high temperature superconducting quantum interference device Kumar, S.; Matthews, R.; Haupt, S. G. Applied Physics Letters, Vol. 70, Issue 8 https://doi.org/10.1063/1.118436	journal	February 1997
Application of superconducting quantum interference devices to nuclear magnetic resonance Greenberg, Ya. S. Reviews of Modern Physics, Vol. 70, Issue 1 https://doi.org/10.1103/RevModPhys.70.175	journal	January 1998
The superconducting quantum interference device microstrip amplifier: Computer models Mück, Michael; Clarke, John Journal of Applied Physics, Vol. 88, Issue 11 https://doi.org/10.1063/1.1321026	journal	December 2000
Liquid-State NMR and Scalar Couplings in Microtesla Magnetic Fields McDermott, R. Science, Vol. 295, Issue 5563 https://doi.org/10.1126/science.1069280	journal	March 2002
Detection of bacteria in suspension by using a superconducting quantum interference device Grossman, H. L.; Myers, W. R.; Vreeland, V. J. Proceedings of the National Academy of Sciences, Vol. 101, Issue 1 https://doi.org/10.1073/pnas.0307128101	journal	December 2003
Whole cortex, 64 channel SQUID biomagnetometer system Vrba, J.; Betts, K.; Burbank, M. IEEE Transactions on Applied Superconductivity, Vol. 3, Issue 1 https://doi.org/10.1109/77.233314	journal	March 1993
Relaxation-Time Measurement and Imaging in the Earth′s Magnetic-Field Planinsic, G.; Stepisink, J.; Kos, M. Journal of Magnetic Resonance, Series A, Vol. 110, Issue 2 https://doi.org/10.1006/jmra.1994.1201	journal	October 1994
Erdfeld-NMR: Apparative Entwicklungen zur In-vivo-Analyse von Körperflüssigkeiten und weichem Gewebe Goedecke, R.; von Boetticher, H. Zeitschrift für Medizinische Physik, Vol. 9, Issue 2 https://doi.org/10.1016/S0939-3889(15)70213-8	journal	January 1999
Three-dimensional phase-encoded chemical shift MRI in the presence of inhomogeneous fields Demas, Vasiliki; Sakellariou, Dimitris; Meriles, Carlos A. Proceedings of the National Academy of Sciences, Vol. 101, Issue 24 https://doi.org/10.1073/pnas.0403016101	journal	June 2004
Novel approaches to low-cost MRI Macovski, Albert; Conolly, Steven Magnetic Resonance in Medicine, Vol. 30, Issue 2 https://doi.org/10.1002/mrm.1910300211	journal	August 1993
Flux-bias stabilization scheme for a radio-frequency amplifier based on a superconducting quantum interference device Mück, Michael; Clarke, John Review of Scientific Instruments, Vol. 72, Issue 9 https://doi.org/10.1063/1.1389498	journal	September 2001
Dynamic nuclear polarization at very low magnetic fields Guiberteau, Thierry; Grucker, Daniel Physics in Medicine and Biology, Vol. 43, Issue 7 https://doi.org/10.1088/0031-9155/43/7/009	journal	July 1998
Development of a Functionalized Xenon Biosensor Spence, Megan M.; Ruiz, E. Janette; Rubin, Seth M. Journal of the American Chemical Society, Vol. 126, Issue 46 https://doi.org/10.1021/ja0483037	journal	November 2004
Broadband SQUID NMR with Room-Temperature Samples Kumar, S.; Thorson, B. D.; Avrin, W. F. Journal of Magnetic Resonance, Series B, Vol. 107, Issue 3 https://doi.org/10.1006/jmrb.1995.1085	journal	June 1995
Radio-frequency amplifier with tenth-kelvin noise temperature based on a microstrip direct current superconducting quantum interference device André, Marc-Olivier; Mück, Michael; Clarke, John Applied Physics Letters, Vol. 75, Issue 5 https://doi.org/10.1063/1.124486	journal	August 1999
Low readout field magnetic resonance imaging of hyperpolarized xenon and water in a single system Shao, Wenjin; Wang, Guodong; Fuzesy, Raymond Applied Physics Letters, Vol. 80, Issue 11 https://doi.org/10.1063/1.1459759	journal	March 2002
Radio-frequency amplifier based on a niobium dc superconducting quantum interference device with microstrip input coupling Mück, Michael; André, Marc-Olivier; Clarke, John Applied Physics Letters, Vol. 72, Issue 22 https://doi.org/10.1063/1.121490	journal	June 1998

Similar Records

Squid detected NMR and MRI at ultralow fields

Patent · Tue May 15 00:00:00 EDT 2007 · OSTI ID:985708

Clarke, John; McDermott, Robert; Pines, Alexander; +1 more

SQUID detected NMR and MRI at ultralow fields

Patent · Tue Oct 03 00:00:00 EDT 2006 · OSTI ID:985708

Clarke, John; McDermott, Robert; Pines, Alexander; +1 more

Squid detected NMR and MRI at ultralow fields

Patent · Tue May 30 00:00:00 EDT 2006 · OSTI ID:985708

Clarke, John; McDermott, Robert; Pines, Alexander; +1 more

Related Subjects

47 OTHER INSTRUMENTATION

Title: Squid detected NMR and MRI at ultralow fields

Citation Formats

References (49)

Similar Records

Related Subjects