Elastic Phase Response of Silica Nanoparticles Buried in Soft Matter

Journal Article · Tue Jan 01 00:00:00 EST 2008 · Applied Physics Letters

DOI:https://doi.org/10.1063/1.2987460· OSTI ID:982718

Tetard, Laurene ^[1]; Passian, Ali ^[1]; Lynch, Rachel M ^[1]; Voy, Brynn H ^[1]; Shekhawat, Gajendra ^[2]; Dravid, Vinayak ^[2]; Thundat, Thomas George ^[1]

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1. ORNL
2. Northwestern University, Evanston

Tracking the uptake of nanomaterials by living cells is an important component in assessing both potential toxicity and in designing future materials for use in vivo. We show that the difference in the local elasticity at the site of silica (SiO{sub 2}) nanoparticles confined within a macrophage enables functional ultrasonic interactions. By elastically exciting the cell, a phase perturbation caused by the buried SiO{sub 2} nanoparticles was detected and used to map the subsurface populations of nanoparticles. Localization and mapping of stiff chemically synthesized silica nanoparticles within the cellular structures of a macrophage are important in basic as well as applied studies.

• Research Organization: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
• Sponsoring Organization: Work for Others (WFO)
• DOE Contract Number: DE-AC05-00OR22725
• OSTI ID: 982718
• Journal Information: Applied Physics Letters, Vol. 93, Issue 13; ISSN 0003-6951
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
ELASTICITY
FUNCTIONALS
IN VIVO
MACROPHAGES
SILICA
TOXICITY
ULTRASONIC WAVES