Portable Analytical Systems for On-Site Diagnosis of Exposure to Pesticides and Nerve Agents

Book · Tue Dec 01 00:00:00 EST 2009

OSTI ID:981580

Lin, Yuehe; Wang, Jun; Liu, Guodong; Timchalk, Chuck

In this chapter, we summarize recent work in our laboratory on the development of sensitive portable analytical systems for use in on-site detection of exposure to organophosphate (OP) pesticides and chemical nerve agents. These systems are based on various nanomaterials functioning as transducers; recognition agents or labels and various elelectrochemical/immunoassay techniques. The studied nanomaterials included functionalized carbon nanotubes (CNT), zirconia nanoparticles (NPs) and quantum dots (QDs). Three biomarkers e.g. the free OPs, metabolites of OPs and protein-OP adducts in biological matrices have been employed for biomonitoring of OP exposure with our developed system. It has been found that the nanomaterial-based portable analytical systems have high sensitivity for the detection of the biomarkers, which suggest that these technologies offer great promise for the rapid and on-site detection and evaluation of OP exposure.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 981580
• Report Number(s): PNNL-SA-59141; 24822; 400412000; TRN: US201013%%793
• Resource Relation: Related Information: Nanoscience and Nanotechnology for Chemical and Biological Defense, ACS Sympoisum Series, 1016:85-98
• Country of Publication: United States
• Language: English

Related Subjects

45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEFENSE
77 NANOSCIENCE AND NANOTECHNOLOGY
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
ADDUCTS
CARBON
DETECTION
DIAGNOSIS
EVALUATION
MATRICES
METABOLITES
NANOTUBES
NERVES
PESTICIDES
QUANTUM DOTS
SENSITIVITY
TRANSDUCERS
USES
WORK
nanoparticles
biosensors
Environmental Molecular Sciences Laboratory