Structural Basis of High-Fidelity DNA Synthesis by Yeast DNA Polymerase δ
Journal Article
·
· Nature Structural and Molecular Biology
OSTI ID:980510
DNA polymerase ? (Pol ?) has a crucial role in eukaryotic replication. Now the crystal structure of the yeast DNA Pol ? catalytic subunit in complex with template primer and incoming nucleotide is presented at 2.0-A resolution, providing insight into its high fidelity and a framework to understand the effects of mutations involved in tumorigenesis.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source
- Sponsoring Organization:
- Doe - Office Of Science
- DOE Contract Number:
- DE-AC02-98CH10886
- OSTI ID:
- 980510
- Report Number(s):
- BNL-93428-2010-JA; TRN: US201015%%1895
- Journal Information:
- Nature Structural and Molecular Biology, Vol. 16; ISSN 1072-8368
- Country of Publication:
- United States
- Language:
- English
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