Characterization of Diffraction-Enhanced Imaging
Diffraction-enhanced imaging (DEI) is a new x-ray imaging modality that has been shown to enhance contrast between normal and cancerous breast tissues. In this study, diffraction-enhanced imaging in computed tomography (DEI-CT) mode was used to quantitatively characterize the refraction contrasts of the organized structures associated with invasive human breast cancer. Using a high-sensitivity Si (3 3 3) reflection, the individual features of breast cancer, including masses, calcifications and spiculations, were observed. DEI-CT yields 14, 5 and 7 times higher CT numbers and 10, 9 and 6 times higher signal-to-noise ratios (SNR) for masses, calcifications and spiculations, respectively, as compared to conventional CT of the same specimen performed using the same detector, x-ray energy and dose. Furthermore, DEI-CT at ten times lower dose yields better SNR than conventional CT. In light of the recent development of a compact DEI prototype using an x-ray tube as its source, these results, acquired at a clinically relevant x-ray energy for which a pre-clinical DEI prototype currently exists, suggest the potential of clinical implementation of mammography with DEI-CT to provide high-contrast, high-resolution images of breast cancer (Parham 2006 PhD Dissertation University of North Carolina at Chapel Hill).
- Research Organization:
- Brookhaven National Laboratory (BNL) National Synchrotron Light Source
- Sponsoring Organization:
- Doe - Office Of Science
- DOE Contract Number:
- AC02-98CH10886
- OSTI ID:
- 980053
- Report Number(s):
- BNL--92971-2010-JA
- Journal Information:
- Physics in Medicine and Biology, Journal Name: Physics in Medicine and Biology Journal Issue: 10 Vol. 54; ISSN 0031-9155; ISSN PHMBA7
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS
COMPUTERIZED TOMOGRAPHY
DOSES
ENERGY
HUMAN POPULATIONS
IMAGES
IMPLEMENTATION
MAMMARY GLANDS
NEOPLASMS
NORTH CAROLINA
POTENTIALS
REFLECTION
REFRACTION
SIGNAL-TO-NOISE RATIO
VISIBLE RADIATION
X-RAY TUBES
YIELDS
national synchrotron light source