Design, Preparation and Activity of Cotton Gauze for Use in Chronic Wound Research

Book · Mon Jan 01 04:00:00 EST 2001

OSTI ID:965171

Edwards, J V; Yager, Dorne; Bopp, Alvin; Diegelmann, Robert F; Goheen, Steven C; Cohen, I K

We consider the rational design and chemical modification of cotton gauze, which is used widely in chronic wounds, to improve wound dressing fibers for application to chronic wound healing. Cotton gauze may be tailored to more effectively enhance the biochemistry of wound healing. The presence of elevated levels of elastase in non-healing wounds has been associated with the degradation of important growth factors and fibronectin necessary for wound healing. In the healing wound a balance of elastase and antiproteases precludes degradation of beneficial proteins from taking place. Cotton gauze modified to release elastase inhibitors or selectively functionalized to sequester elastase provides a dressing that decreases high levels of destructive elastase in the chronic wounds. Three approaches have been taken to explore the potential of fiber-inhibitors useful in chronic wounds: 1) Formulation of inhibitors on the dressing; 2) Synthesis of elastase recognition sequences on cotton cellulose; and 3) Data presented here on carboxymethylating, and oxidizing textile finishes of cotton gauze to remove elastase from the wound.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 965171
• Report Number(s): PNNL-SA-32331
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BIOCHEMISTRY
CELLULOSE
COTTON
DESIGN
FIBERS
GROWTH FACTORS
HEALING
MODIFICATIONS
PROTEINS
SYNTHESIS
TEXTILES
WOUNDS