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Sentra : a database of signal transduction proteins for comparative genome analysis.

Journal Article · · Nucleic Acids Res.
DOI:https://doi.org/10.1093/nar/gkl949· OSTI ID:962543
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Sentra (http://compbio.mcs.anl.gov/sentra), a database of signal transduction proteins encoded in completely sequenced prokaryotic genomes, has been updated to reflect recent advances in understanding signal transduction events on a whole-genome scale. Sentra consists of two principal components, a manually curated list of signal transduction proteins in 202 completely sequenced prokaryotic genomes and an automatically generated listing of predicted signaling proteins in 235 sequenced genomes that are awaiting manual curation. In addition to two-component histidine kinases and response regulators, the database now lists manually curated Ser/Thr/Tyr protein kinases and protein phosphatases, as well as adenylate and diguanylate cyclases and c-di-GMP phosphodiesterases, as defined in several recent reviews. All entries in Sentra are extensively annotated with relevant information from public databases (e.g. UniProt, KEGG, PDB and NCBI). Sentra's infrastructure was redesigned to support interactive cross-genome comparisons of signal transduction capabilities of prokaryotic organisms from a taxonomic and phenotypic perspective and in the framework of signal transduction pathways from KEGG. Sentra leverages the PUMA2 system to support interactive analysis and annotation of signal transduction proteins by the users.
Research Organization:
Argonne National Laboratory (ANL)
Sponsoring Organization:
SC; NIH; GLRCE
DOE Contract Number:
AC02-06CH11357
OSTI ID:
962543
Report Number(s):
ANL/MCS/JA-57931
Journal Information:
Nucleic Acids Res., Journal Name: Nucleic Acids Res. Journal Issue: Jan. 2007 Vol. 35; ISSN 0305-1048; ISSN NARHAD
Country of Publication:
United States
Language:
ENGLISH

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CYCLASES
HISTIDINE
PHOSPHATASES
PHOSPHODIESTERASES
PHOSPHOTRANSFERASES
PROTEINS