The CCL3L1-CCR5 genotype influences the development of AIDS, but not HIV susceptibility or the response to HAART

Journal Article · Tue Jan 01 04:00:00 EST 2008 · Nature Medicine

OSTI ID:960867

Bhattacharya, Tanmoy ^[1]; Stanton, Jennifer ^[2]; Kim, Eun - Young ^[2]; Kunstman, Kevin ^[2]; Phair, John ^[2]; Jacobson, Lisa P ^[3]; Wolinsky, Steven M ^[2]

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1. Los Alamos National Laboratory
2. NORTHWESTERN UNIV
3. JOHNS HOPKINS UNIV

A selective advantage against infectious diseases such as HIV/AIDS is associated with differences in the genes relevant to immunity and virus replication. The CC chemokine receptor 5 (CCR5), the principal coreceptor for HIV, and its chemokine ligands, including CCL3L1, influences the CD4+ target cells susceptibility to infection. The CCL3L1 gene is in a region of segmental duplication on the q-arm of human chromosome 17. Increased numbers of CCL3L1 gene copies that affect the gene expression phenotype might have substantial protective effects. Here we show that the population-specific CCL3L1 gene copy number and the CCR5 {Delta}32 protein-inactivating deletion that categorizes the CCL3L1-CCR5 genotype do not influence HIV/AIDS susceptibility or the robustness of immune recovery after the initiation of highly active antiretroviral therapy (HAART).

• Research Organization: Los Alamos National Laboratory (LANL)
• Sponsoring Organization: DOE
• DOE Contract Number: AC52-06NA25396
• OSTI ID: 960867
• Report Number(s): LA-UR-08-07711; LA-UR-08-7711
• Journal Information: Nature Medicine, Journal Name: Nature Medicine
• Country of Publication: United States
• Language: English

Related Subjects

55
AIDS
AIDS VIRUS
GENES
GENOTYPE
HUMAN CHROMOSOME 17
IMMUNITY
INFECTIOUS DISEASES
LIGANDS
LYMPHOCYTES
PHENOTYPE
RECEPTORS
THERAPY