Preparation and characterization of a tritiated derivative of CP-96.345-a nonpeptide antagonist of the substance P receptor-with a high specific radioactivity
Journal Article
·
· Russian Journal of Bioorganic Chemistry
OSTI ID:96069
- Institute of Biorganic Chemistry, Moscow (Russian Federation)
- Institute of Molecular Genetics, Moscow (Russian Federation)
A tritiated derivative of CP-96.345 with a specific activity of 84 Ci/mmole has been obtained. The radioactive compound has been characterized in comparison with the unlabeled analogue for its capacity for inhibiting the binding of the [{sup 125}I]iodinated derivative of substance P with brain membrane preparations from various sources. The capacity of [{sup 3}H]CP-96.345 for directly and specifically binding with membranes from the same sources has also been investigated by the method of radioligand analysis.
- OSTI ID:
- 96069
- Journal Information:
- Russian Journal of Bioorganic Chemistry, Journal Name: Russian Journal of Bioorganic Chemistry Journal Issue: 11 Vol. 20; ISSN RJBCET; ISSN 1068-1620
- Country of Publication:
- United States
- Language:
- English
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