jConsequences of two different doses to the lungs during a single dose of total body irradiation: Results of a radomized study on 85 patients

Journal Article · Tue Nov 15 04:00:00 EST 1994 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/0360-3016(94)90355-7· OSTI ID:96060

Girinsky, T; Socie, G; Ammarguellat, H ^[1]

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1. Institut Gustave-Roussy, Villejuif (France); and others

To evaluate the incidence of lung complications and leukemia recurrences after two different doses to the lungs during total body irradiation. Seventy-nine patients with acute leukemia (AML or ALL) in first complete remission or chronic myeloid leukemia in the chronic phase, five patients with high grade lymphoma, and one with chronic lymphocytic leukemia were entered in the study. They were given a single dose of total body irradiation (10 Gy over 4 h) with two different doses to the lungs (6 Gy or 8 Gy) prior to bone marrow transplantation. The median dose rate was 0.04 Gy/min. The median follow-up for both groups of patients was 24 months. The actuarial 5-year overall survival rate was similar in both groups, 59% and 43% for patients given 8 Gy and 6 Gy to the lungs, respectively. The lung complication rate was similar in the two groups (28% vs. 22% for the 8 Gy and 6 Gy group, respectively). The actuarial leukemia recurrence rate was significantly higher in the group of patients given 6 Gy to the lungs (25%) vs. 0% in the 8 Gy group. Interestingly, fall recurrences occurred in the group of patients who were given 6 Gy to the lungs, who had acute leukemia, and no chromic graft vs. host disease (GVHD). Although the number of patients was not very large and the follow-up relatively short, these findings suggest that a lower dose to the lungs could lead to an increased incidence of leukemia recurrences due to a lower dose to the thoracic wall or to a lower incidence of chronic GVHD. 9 refs., 4 figs., 1 tab.

• Sponsoring Organization: USDOE
• OSTI ID: 96060
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 4 Vol. 30; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
DELAYED RADIATION EFFECTS
DISEASE INCIDENCE
DOSE-RESPONSE RELATIONSHIPS
LEUKEMIA
LUNGS
WHOLE-BODY IRRADIATION