Proteins, fluctuations and complexity
Journal Article
·
· Philosophical Magazine
OSTI ID:960459
- Los Alamos National Laboratory
Glasses, supercooled liquids, and proteins share common properties, in particular the existence of two different types of fluctuations, {alpha} and {beta}. While the effect of the {alpha} fluctuations on proteins has been known for a few years, the effect of {beta} fluctuations has not been understood. By comparing neutron scattering data on the protein myoglobin with the {beta} fluctuations in the hydration shell measured by dielectric spectroscopy we show that the internal protein motions are slaved to these fluctuations. We also show that there is no 'dynamic transition' in proteins near 200 K. The rapid increase in the mean square displacement with temperature in many neutron scattering experiments is quantitatively predicted by the {beta} fluctuations in the hydration shell.
- Research Organization:
- Los Alamos National Laboratory (LANL)
- Sponsoring Organization:
- DOE
- DOE Contract Number:
- AC52-06NA25396
- OSTI ID:
- 960459
- Report Number(s):
- LA-UR-08-04866; LA-UR-08-4866
- Journal Information:
- Philosophical Magazine, Journal Name: Philosophical Magazine
- Country of Publication:
- United States
- Language:
- English
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