Functional analysis of natural microbial consortia using community proteomics

Journal Article · Thu Jan 01 04:00:00 EST 2009 · Nature Reviews Microbiology

DOI:https://doi.org/10.1038/nrmicro2080· OSTI ID:958913

Verberkmoes, Nathan C ^[1]; Denef, Vincent ^[2]; Banfield, Jillian F. ^[2]

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1. ORNL
2. University of California, Berkeley

It is widely accepted that microbial communities, not individual microorganisms, are the relevant ecological units, yet what we know about metabolic functioning of microbial communities could be written on a postage stamp. The recent developments in comprehensive molecular methods promise to gain a better understanding of how organisms within communities interact and how communities and their populations evolve. Here we highlight recent advances and insights gathered by the application of proteogenomics to microbial communities. We explore the history of how unrelated fields of microbial ecology, genomics, biological mass spectrometry and informatics converge to the development of a new field of metaproteomics.

• Research Organization: Oak Ridge National Laboratory (ORNL)
• Sponsoring Organization: SC USDOE - Office of Science (SC)
• DOE Contract Number: AC05-00OR22725
• OSTI ID: 958913
• Journal Information: Nature Reviews Microbiology, Journal Name: Nature Reviews Microbiology Journal Issue: 3 Vol. 7
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS
COMMUNITIES
ECOLOGY
FUNCTIONAL ANALYSIS
MASS SPECTROSCOPY
METABOLISM
MICROORGANISMS