An Isotropic Chemical Shift-Chemical Shift Anisotropic Correlation Experiment Using Discrete Magic Angle Turning

Journal Article · Fri May 01 04:00:00 EDT 2009 · Journal of Magnetic Resonance, 198(1):105-110

DOI:https://doi.org/10.1016/j.jmr.2009.01.027· OSTI ID:957352

Hu, Jian Z; Sears, Jesse A; Kwak, Ja Hun; Hoyt, David W; Wang, Yong; Peden, Charles HF

An isotropic-anisotropic shift 2D correlation spectroscopy is introduced that combines the advantages of both magic angle turning (MAT) and magic angle hopping (MAH) technologies. In this new approach, denoted DMAT for "discrete magic angle turning", the sample rotates clockwise followed by an anticlockwise rotation of exactly the same amount with each rotation less or equal than 360 degrees but greater than 240 degrees, with the rotation speed being constant only for times related to the evolution dimension. This back and forth rotation is repeated and synchronized with a special radio frequency (RF) pulse sequence to produce an isotropic-anisotropic shift 2D correlation spectrum. For any spin-interaction of rank-2 such as chemical shift anisotropy, isotropic magnetic susceptibility interaction, and residual homonuclear dipolar interaction in biological fluid samples, the projection along the isotropic dimension is a high resolution spectrum. Since a less than 360 degrees sample rotation is involved, the design potentially allows for in situ control over physical parameters such as pressure, flow conditions, feed compositions, and temperature so that true in-situ NMR investigations can be carried out.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 957352
• Report Number(s): PNNL-SA-63634; 26196; 19799; 9103a; KC0302010
• Journal Information: Journal of Magnetic Resonance, 198(1):105-110, Journal Name: Journal of Magnetic Resonance, 198(1):105-110 Journal Issue: 1 Vol. 198; ISSN 1090-7807; ISSN JMARF3
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
ANISOTROPY
CHEMICAL SHIFT
Environmental Molecular Sciences Laboratory
ISOTROPY
MAGNETIC SUSCEPTIBILITY
NUCLEAR MAGNETIC RESONANCE
RESOLUTION
ROTATION
TWO-DIMENSIONAL CALCULATIONS