Membrane architectures for ion-channel switch-based electrochemical biosensors

Patent · Tue Oct 28 00:00:00 EDT 2008

OSTI ID:957014

Sansinena, Jose-Maria ^[1]; Redondo, Antonio ^[1]; Swanson, Basil I ^[1]; Yee, Chanel Kitmon ^[2]; Parikh, Atul N ^[3]; Yang, Calvin ^[2]

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1. Los Alamos, NM
2. Davis, CA
3. Woodland, CA

The present invention is directed to a process of forming a bilayer lipid membrane structure by depositing an organic layer having a defined surface area onto an electrically conductive substrate, removing portions of said organic layer upon said electrically conductive substrate whereby selected portions of said organic layer are removed to form defined voids within said defined surface area of said organic layer and defined islands of organic layer upon said electrically conductive substrate, and, depositing a bilayer lipid membrane over the defined voids and defined islands of organic layer upon said substrate whereby aqueous reservoirs are formed between said electrically conductive substrate and said bilayer lipid membrane, said bilayer lipid membrane characterized as spanning across the defined voids between said defined islands. A lipid membrane structure is also described together with an array of such lipid membrane structure.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM
• Sponsoring Organization: United States Department of Energy
• DOE Contract Number: W-7405-ENG-36
• Assignee: Los Alamos National Security, LLC (Los Alamos, NM)
• Patent Number(s): 7,442,403
• Application Number: 11/072,720
• OSTI ID: 957014
• Country of Publication: United States
• Language: English