Trafficking of ErbB receptors and its influence on signaling

Journal Article · Sun Mar 09 23:00:00 EST 2003 · Experimental Cell Research, 284(1):78-88

DOI:https://doi.org/10.1016/S0014-4827(03)00002-8· OSTI ID:949173

Wiley, H S

Although members of the ErbB receptor family are found predominatly at the cell surface, these receptors undergo constant cycling between the plasma membrane and the endosomal compartment. In the absence of an activating ligand, these receptors are slowly internalized (t 1/2 ~ 30 min) are quickly recycled.The constitutive degradation rate of the epidermal growth factor (EGF) receptor (EGFR) is slower than other ErbB family members and only the EGFR appears to alter its trafficking pattern in response to ligand binding. Continued...

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 949173
• Report Number(s): PNNL-SA-41391
• Journal Information: Experimental Cell Research, 284(1):78-88, Journal Name: Experimental Cell Research, 284(1):78-88 Journal Issue: 1 Vol. 284; ISSN 0014-4827; ISSN ECREAL
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
COMPARTMENTS
GROWTH FACTORS
MEMBRANES
PLASMA
PROTEINS
SUBSTRATES
Trafficking of the ErbB receptors