Synthesis of a Benzodiazepine-derived Rhodium NHC Complex by C-H Bond Activation
Journal Article
·
· Organometallics
OSTI ID:948126
The synthesis and characterization of a Rh(I)-NHC complex generated by C-H activation of 1,4-benzodiazepine heterocycle are reported. This complex constitutes a rare example of a carbene tautomer of a 1,4-benzodiazepine aldimine stabilized by transition metal coordination and demonstrates the ability of the catalytically relevant RhCl(PCy{sub 3}){sub 2} fragment to induce NHC-forming tautomerization of heterocycles possessing a single carbene-stabilizing heteroatom. Implications for the synthesis of benzodiazepines and related pharmacophores via C-H functionalization are discussed.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- Chemical Sciences Division
- DOE Contract Number:
- DE-AC02-05CH11231
- OSTI ID:
- 948126
- Report Number(s):
- LBNL-1478E; ORGND7; TRN: US200906%%126
- Journal Information:
- Organometallics, Journal Name: Organometallics; ISSN 0276-7333
- Country of Publication:
- United States
- Language:
- English
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