Controlled translocation of DNA segments through nanoelectrode gaps

Journal Article · Tue Jan 01 04:00:00 EST 2008 · Journal of Physical Chemistry C

DOI:https://doi.org/10.1021/jp709652y· OSTI ID:944945

Zhao, Xiongce ^[1]; Payne, Christina M ^[2]; Cummings, Peter T ^[1]

---

1. ORNL
2. Vanderbilt University

Molecular dynamics simulations show that electrophoresis of DNA segments through a nanoscale electrode gap can be controlled by applying appropriate biased voltages in the transmembrane direction. The translocation velocities are dependent on both the DNA molecular weight and nucleotide structure. Application of alternating driving fields results in oscillatory motion of DNA inside the gap. Interruption of the driving field can effectively pause the translocation of DNA segments. Results from this work are useful for designing novel sequencing devices.

• Research Organization: Oak Ridge National Laboratory (ORNL); Center for Nanophase Materials Sciences
• Sponsoring Organization: SC USDOE - Office of Science (SC)
• DOE Contract Number: AC05-00OR22725
• OSTI ID: 944945
• Journal Information: Journal of Physical Chemistry C, Journal Name: Journal of Physical Chemistry C Journal Issue: 1 Vol. 112; ISSN 1932-7455; ISSN 1932-7447
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DNA
ELECTRODES
ELECTROPHORESIS
MOLECULAR WEIGHT
NUCLEOTIDES
TRANSLOCATION