Biological preconcentrator
- Albuquerque, NM
A biological preconcentrator comprises a stimulus-responsive active film on a stimulus-producing microfabricated platform. The active film can comprise a thermally switchable polymer film that can be used to selectively absorb and desorb proteins from a protein mixture. The biological microfabricated platform can comprise a thin membrane suspended on a substrate with an integral resistive heater and/or thermoelectric cooler for thermal switching of the active polymer film disposed on the membrane. The active polymer film can comprise hydrogel-like polymers, such as poly(ethylene oxide) or poly(n-isopropylacrylamide), that are tethered to the membrane. The biological preconcentrator can be fabricated with semiconductor materials and technologies.
- Research Organization:
- Sandia National Laboratories (SNL-NM), Albuquerque, NM
- Sponsoring Organization:
- United States Department of Energy
- DOE Contract Number:
- AC04-94AL85000
- Assignee:
- Sandia Corporation (Albuquerque, NM)
- Patent Number(s):
- 7,422,724
- Application Number:
- 10/214,891
- OSTI ID:
- 943499
- Country of Publication:
- United States
- Language:
- English
Sample pretreatment on microfabricated devices
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journal | February 2002 |
Synthesis of Poly( N- isopropylacrylamide) on Initiator-Modified Self-Assembled Monolayers
|
journal | May 2001 |
A new fabrication process for planar thin-film multijunction thermal converters
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journal | April 2001 |
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