The Structure of the GAF A Domain from Phosphodiesterase 6c Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-Dependent Conformational Change
Journal Article
·
· Journal of Biological Chemistry, 283(38):25913-25919
The photoreceptor phosphodiesterase (PDE6) regulates the intracellular levels of the second messenger cGMP in the outer segments of cone and rod photoreceptor cells. PDE6 contains two regulatory GAF domains, of which one (GAF A) binds cGMP and regulates the activity of the PDE6 holoenzyme.
- Research Organization:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 939343
- Journal Information:
- Journal of Biological Chemistry, 283(38):25913-25919, Journal Name: Journal of Biological Chemistry, 283(38):25913-25919 Journal Issue: 38 Vol. 283; ISSN JBCHA3; ISSN 0021-9258
- Country of Publication:
- United States
- Language:
- English
Similar Records
Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: Insights into Nucleotide Specificity, Dimerization, and cGMP-Dependent Conformational Change
Conformation changes, N-terminal involvement and cGMP signal relay in phosphodiesterase-5 GAF domain
Conformation Changes N-terminal Involvement and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain
Journal Article
·
Fri Aug 15 00:00:00 EDT 2008
· Journal of Biological Chemistry, 283(33):22749-22759
·
OSTI ID:937368
Conformation changes, N-terminal involvement and cGMP signal relay in phosphodiesterase-5 GAF domain
Journal Article
·
Thu Dec 02 23:00:00 EST 2010
· Journal of Biological Chemistry
·
OSTI ID:1040560
Conformation Changes N-terminal Involvement and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain
Journal Article
·
Fri Dec 30 23:00:00 EST 2011
· Journal of Biological Chemistry
·
OSTI ID:1041739