Automated High Throughput Drug Target Crystallography

Journal Article · Fri Feb 18 04:00:00 EST 2005 · American Pharmaceutical Review, N/A, no. 9/10, September 1, 2005, pp. 14

OSTI ID:936949

Rupp, B

The molecular structures of drug target proteins and receptors form the basis for 'rational' or structure guided drug design. The majority of target structures are experimentally determined by protein X-ray crystallography, which as evolved into a highly automated, high throughput drug discovery and screening tool. Process automation has accelerated tasks from parallel protein expression, fully automated crystallization, and rapid data collection to highly efficient structure determination methods. A thoroughly designed automation technology platform supported by a powerful informatics infrastructure forms the basis for optimal workflow implementation and the data mining and analysis tools to generate new leads from experimental protein drug target structures.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA
• Sponsoring Organization: USDOE
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 936949
• Report Number(s): UCRL-JRNL-209860
• Journal Information: American Pharmaceutical Review, N/A, no. 9/10, September 1, 2005, pp. 14, Journal Name: American Pharmaceutical Review, N/A, no. 9/10, September 1, 2005, pp. 14 Journal Issue: 9/10
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AUTOMATION
CRYSTALLIZATION
CRYSTALLOGRAPHY
DESIGN
IMPLEMENTATION
MINING
MOLECULAR STRUCTURE
PROTEINS
TARGETS