Assessing the pulmonary toxicity of single-walled carbon nanohorns

Journal Article · Mon Jan 01 04:00:00 EST 2007 · Nanotoxicology

DOI:https://doi.org/10.1080/17435390701598496· OSTI ID:932105

Lynch, Rachel M ^[1]; Voy, Brynn H ^[1]; Glass-Mattie, Dana F ^[1]; Mahurin, Shannon Mark ^[1]; Saxton, Arnold ^[2]; Donnel, Robert L. ^[2]; Cheng, Mengdawn ^[1]

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1. ORNL
2. University of Tennessee, Knoxville (UTK)

Previous studies have suggested that single-walled carbon nanotubes (SWCNTs) may be pose a pulmonary hazard. We investigated the pulmonary toxicity of single-walled carbon nanohorns (SWCNHs), a relatively new carbon-based nanomaterial that is structurally similar to SWCNTs. Mice were exposed to 30 g of surfactant-suspended SWCNHs by pharyngeal aspiration and sacrificed 24 hours or 7 days post exposure. Total and differential cell counts and cytokine analysis of bronchoalveolar lavage fluid demonstrated a mild inflammatory response which was mitigated by day 7 post exposure. Whole lung microarray analysis demonstrated that SWCNH-exposure did not lead to robust changes in gene expression. Finally, histological analysis showed no evidence of granuloma formation or fibrosis following SWCNH aspiration. These combined results suggest that SWCNH is a relatively innocuous nanomaterial when delivered to mice in vivo using aspiration as a delivery mechanism.

• Research Organization: Oak Ridge National Laboratory (ORNL); Mouse Genetics Research Facility
• Sponsoring Organization: ORNL LDRD Director's R&D; SC USDOE - Office of Science (SC)
• DOE Contract Number: AC05-00OR22725
• OSTI ID: 932105
• Journal Information: Nanotoxicology, Journal Name: Nanotoxicology Journal Issue: 2 Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

Single-walled carbon nanohorns
aspiration
inflammatory
nanotoxicology