Evolution of a Focal Brain Lesin Produced by Interlaced Microplanar X-rays
Stereotactic radiosurgery has led to advances in the treatment of central nervous system disease. It relies upon the principle of delivering relatively high dose irradiation to a precise target, while exposing surrounding tissues to extremely low doses. We describe a novel radiosurgical approach using interlaced microplanar X-rays which we have termed 'microradiosurgery.' The use of microbeams allows for 1000-times greater precision than current clinically employed techniques. As a demonstration of this new method, we produced a -3.8 mm{sup 3} lesion in the rat brain. The lesion was followed over a period of 216 days using 9.4 Tesla magnetic resonance imaging. Our results show a gradually developing lesion at the site of the interlaced beams. The lesion began as a high T2 signal only, but advanced to include a central area of low T1 and mixed T2 signal within 2 months. No lesion was observed in the other side of the brain which was exposed to non-interlaced microbeams only. Interlaced microbeams is an effective method to create focal brain microlesions. This technique may allow the future treatment of pathology not accessible by surgical or more traditional radiosurgical means.
- Research Organization:
- Brookhaven National Laboratory (BNL) National Synchrotron Light Source
- Sponsoring Organization:
- Doe - Office Of Science
- DOE Contract Number:
- AC02-98CH10886
- OSTI ID:
- 929981
- Report Number(s):
- BNL--80588-2008-JA
- Journal Information:
- Minimally Invasive Neurosurgery, Journal Name: Minimally Invasive Neurosurgery Vol. 50
- Country of Publication:
- United States
- Language:
- English
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