Comment on ``Experimental Free Energy Reconstruction From Single-Molecule Force Spectroscopy Using Jarzynski's Equality''
Journal Article
·
· Physical Review Letters
Harris, Song and Kiang [1] (HSK) describe their results on reconstructing the free energy profiles for both the stretch of the titin polymer, and the unfolding of an individual I27 domain. The new finding reported in [1] is the measurement of the free energy barrier (or activation energy) to unfolding the I27 domain. Due to a misinterpretation of the mechanics involved, the free energy surface (and thus the energy barrier) to unfolding the I27 domain was not measured.
- Research Organization:
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 928521
- Report Number(s):
- LLNL-JRNL-400499; PRLTAO; TRN: US0803279
- Journal Information:
- Physical Review Letters, Vol. 100, Issue 1; ISSN 0031-9007
- Country of Publication:
- United States
- Language:
- English
Free energy reconstruction from nonequilibrium single-molecule pulling experiments
|
journal | March 2001 |
Experimental Free Energy Surface Reconstruction from Single-Molecule Force Spectroscopy using Jarzynski’s Equality
|
journal | August 2007 |
Free Energy Surfaces from Single-Molecule Force Spectroscopy
|
journal | July 2005 |
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