Vesicle-based method and apparatus for collecting, manipulating, and chemically processing trace macromolecular species

Davalos, Rafael V; Ellis, Christopher R. B.

Title: Vesicle-based method and apparatus for collecting, manipulating, and chemically processing trace macromolecular species

Patent · Tue Mar 04 00:00:00 EST 2008

OSTI ID:927853

Davalos, Rafael V ^[1]; Ellis, Christopher R. B. ^[1]

Oakland, CA

Disclosed is an apparatus and method for inserting one or several chemical or biological species into phospholipid containers that are controlled within a microfluidic network, wherein individual containers are tracked and manipulated by electric fields and wherein the contained species may be chemically processed.

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Research Organization:: Sandia Corporation (Livermore, CA)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC04-94AL85000

Assignee:: Sandia Corporation (Livermore, CA)

Patent Number(s):: 7,338,796

Application Number:: 10/914,991

OSTI ID:: 927853

Country of Publication:: United States

Language:: English

References (7)

Chemical Transformations in Individual Ultrasmall Biomimetic Containers Chiu, D. T. Science, Vol. 283, Issue 5409 https://doi.org/10.1126/science.283.5409.1892	journal	March 1999
A Comparison of Theoretical and Experimental Electrokinetic and Dielectrophoretic Flow Fields (Invited) Cummings, Eric 32nd AIAA Fluid Dynamics Conference and Exhibit https://doi.org/10.2514/6.2002-3193	conference	June 2012
Electrofusion: A biophysical modification of cell membrane and a mechanism in exocytosis Ramos, Corinne; Teissié, Justin Biochimie, Vol. 82, Issue 5 https://doi.org/10.1016/S0300-9084(00)00200-5	journal	May 2000
Electroporation of cell membranes Tsong, T. Y. Biophysical Journal, Vol. 60, Issue 2 https://doi.org/10.1016/S0006-3495(91)82054-9	journal	August 1991
Electroporation: Bio-Electrochemical Mass Transfer at the Nano Scale Davalos, Rafael; Huang, Yong; Rubinsky, Boris Microscale Thermophysical Engineering, Vol. 4, Issue 3, p. 147-159 https://doi.org/10.1080/10893950050148115	journal	July 2000
Giant Vesicles as Biochemical Compartments: The Use of Microinjection Techniques Bucher, Patricia; Fischer, Aline; Luisi, Pier Luigi Langmuir, Vol. 14, Issue 10 https://doi.org/10.1021/la971318g	journal	May 1998
Giant vesicles as models to study the interactions between membranes and proteins Fischer, Aline; Oberholzer, Thomas; Luisi, Pier Luigi Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1467, Issue 1 https://doi.org/10.1016/S0005-2736(00)00217-0	journal	July 2000

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