Application of proteomics in the discovery of candidate protein biomarkers in a Diabetes Autoantibody Standardization Program sample subset

Journal Article · Fri Feb 01 00:00:00 EST 2008 · Journal of Proteome Research, 7(2):698-707

DOI:https://doi.org/10.1021/pr700606w· OSTI ID:925477

Metz, Thomas O; Qian, Weijun; Jacobs, Jon M; Gritsenko, Marina A; Moore, Ronald J; Polpitiya, Ashoka D; Monroe, Matthew E; Camp, David G; mueller, Patricia W; Smith, Richard D

Objective. Before biomarkers predictive of type 1 diabetes can be evaluated in proficiency evaluations, they must be identified and validated in initial, exploratory studies. Hypothesis-driven comparative studies may be performed to identify candidate biomarkers but are limited to the current knowledge of metabolic, signaling, and inflammatory pathways in the context of type 1 diabetes. Alternatively, untargeted “-omics” approaches may be employed in profiling studies to identify candidate biomarkers of type 1 diabetes.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 925477
• Report Number(s): PNNL-SA-56533; 12500a; 400412000; TRN: US200809%%633
• Journal Information: Journal of Proteome Research, 7(2):698-707, Vol. 7, Issue 2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
PROTEINS
STANDARDIZATION
BATTELLE PACIFIC NORTHWEST LABORATORIES
Environmental Molecular Sciences Laboratory