Pseudomonas aeruginosa forms Biofilms in Acute InfectionIndependent of Cell-to-Cell Signaling
Biofilms are bacterial communities residing within a polysaccharide matrix that are associated with persistence and antibiotic resistance in chronic infections. We show that the opportunistic pathogen Pseudomonas aeruginosa forms biofilms within 8 hours of infection in thermally-injured mice, demonstrating that biofilms contribute to bacterial colonization in acute infections. P. aeruginosa biofilms were visualized within burned tissue surrounding blood vessels and adipose cells. Although quorum sensing (QS), a bacterial signaling mechanism, coordinates differentiation of biofilms in vitro, wild type and QS-deficient P. aeruginosa formed similar biofilms in vivo. Our findings demonstrate that P. aeruginosa forms biofilms on specific host tissues independent of QS.
- Research Organization:
- COLLABORATION - Texas TechU.
- DOE Contract Number:
- AC02-05CH11231
- OSTI ID:
- 923645
- Report Number(s):
- LBNL--61664; BnR: YN0100000
- Journal Information:
- Infection and Immunity, Journal Name: Infection and Immunity Journal Issue: 8 Vol. 75; ISSN 0019-9567; ISSN INFIBR
- Country of Publication:
- United States
- Language:
- English
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