Disruption of Maternal DNA Repair Increases Sperm-DerivedChromosomal Aberrations
Journal Article
·
· Proceedings of the National Academy ofSciences
OSTI ID:922724
The final weeks of male germ cell differentiation occur in aDNA repair-deficient environment and normal development depends on theability of the egg to repair DNA damage in the fertilizing sperm. Geneticdisruption of maternal DNA double-strand break repair pathways in micesignificantly increased the frequency of zygotes with chromosomalstructural aberrations after paternal exposure to ionizing radiation.These findings demonstrate that radiation-induced DNA sperm lesions arerepaired after fertilization by maternal factors and suggest that geneticvariation in maternal DNA repair can modulate the risk of early pregnancylosses and of children with chromosomal aberrations of paternalorigin.
- Research Organization:
- Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
- Sponsoring Organization:
- USDOE Director, Office of Science; National Institutes ofHealth
- DOE Contract Number:
- AC02-05CH11231
- OSTI ID:
- 922724
- Report Number(s):
- LBNL--62441; BnR: 600305000
- Journal Information:
- Proceedings of the National Academy ofSciences, Journal Name: Proceedings of the National Academy ofSciences Journal Issue: 45 Vol. 104
- Country of Publication:
- United States
- Language:
- English
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