The Fusarium Graminearum Genome Reveals a Link Between Localized Polymorphism and Pathogen Specialization
We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 921228
- Report Number(s):
- PNNL-SA-57387; SCEHDK; BM0102070; TRN: US200804%%1509
- Journal Information:
- Science, 317(5843):1400-1402, Vol. 317, Issue 5843; ISSN 0193-4511
- Country of Publication:
- United States
- Language:
- English
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