Radobiologic effects in the population living near Chernobyl
- Univ. of Cincinnati, OH (United States)
- Univ. of California, San Francisco, CA (United States)
- Indiana Univ., South Bend, IN (United States)
- Univ. of Pittsburgh, PA (United States)
- Lawrence Livermore National Laboratory, CA (United States)
Eightly citizens of the former Soviet Union were examined after immigrating to the U.S. from 1989-91. During the Chernobyl nuclear reactor accident, they were residents of four cities (Kiev, Gomel, Bobrujsk and Mozyr) all located 100-200 km from the plant. Examination of each individual included one - four whole-body radiation counts and a cytogenetic analysis of mitogen-stimulated peripheral blood lymphocytes for micronuclei as a biomarker of chromosome damage. In addition, 19 of the subjects heterozygous for the MN blood group were further tested using the glycophorin-A (GPA) specific locus mutation assay on erythrocytes. Results showed 48 immigrants including persons from all four cities had detectable levels of radiocesium contamination. The highest body burdens were found in a family who had lived in Mozyr, about 100 km northwest of Chernobyl. The observed decline in radiocesium of these subjects was consistent with the published biological half-life of {sup 137}Cs. Adults showed the highest body burdens of radiocesium and the adult males from all four cities consistently showed higher levels than adult females. Age was found to account for much of the variation of lymphocyte micronuclei, however, a significant correlation was also demonstrated with radiocesium body burden and the absorbed dose for 20 subjects. Consistent with earlier studies, the frequency of simple allele loss (N/O) variants at the autosomal GPA locus was significantly higher than age- and sex-matched contemporaneous controls. Nine of the 19 MN heterozygotes showed variant frequencies 4-fold higher than mean frequency of matched controls. The allele loss mutations also showed a significant positive correlation with the radiocesium body burden. Results from this study indicate individuals living as far as 100-200 km from Chernobyl received radiation exposure from fallout sufficient to induce both cytogenetic abnormalities and specific locus mutations in hematopoietic tissues.
- OSTI ID:
- 91983
- Report Number(s):
- CONF-9405324--
- Journal Information:
- Environmental and Molecular Mutagenesis, Journal Name: Environmental and Molecular Mutagenesis Journal Issue: Suppl.23 Vol. 23; ISSN 0893-6692; ISSN EMMUEG
- Country of Publication:
- United States
- Language:
- English
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