VIPER: an advanced software package to support high-throughput LC-MS peptide identification

Journal Article · Fri Jun 01 04:00:00 EDT 2007 · Bioinformatics, 23(15- August 2007):2021-2023

DOI:https://doi.org/10.1093/bioinformatics/btm281· OSTI ID:919698

Monroe, Matthew E; Tolic, Nikola; Jaitly, Navdeep; Shaw, Jason L; Adkins, Joshua N; Smith, Richard D

High throughput liquid chromatograph-mass spectrometry (LC-MS) based proteomics analyses have necessitated development of software to manipulate large volumes of detailed data and produce confident peptide/protein identifications. VIPER unites important data processing steps in a single software package that can be used to visualize peptide mass and LC elution (i.e. retention) time “feature” relationships from individual analyses, match these LC-MS features to accurate mass and time (AMT) tags of peptides previously identified in LC-MS/MS analyses, and to identify and quantify pairs of isotopically labeled peptides.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 919698
• Report Number(s): PNNL-SA-52622; 400412000
• Journal Information: Bioinformatics, 23(15- August 2007):2021-2023, Journal Name: Bioinformatics, 23(15- August 2007):2021-2023 Vol. 23
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
DATA ANALYSIS
LIQUID COLUMN CHROMATOGRAPHY
MASS SPECTROSCOPY
PEPTIDES
PROTEINS
V CODES