Biocompatible self-assembly of nano-materials for Bio-MEMS and insect reconnaissance.

Technical Report · Sun Nov 30 23:00:00 EST 2003

DOI:https://doi.org/10.2172/918382· OSTI ID:918382

Brozik, Susan Marie; Brinker, C Jeffrey; Dunphy, Darren Robert; Sinclair, Michael B; Manginell, Monica; Ashley, Carlee E ^[1]; Timlin, Jerilyn Ann; Werner-Washburne, Margaret C ^[1]; Calvert, Paul Davidson ^[2]; Hartenberger, Tamara N; Flemming, Jeb Hunter; Baca, Helen Kennicott ^[1]

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1. University of New Mexico, Albuquerque, NM
2. University of Massachusetts - Dartmouth, Dartmouth, MA

This report summarizes the development of new biocompatible self-assembly procedures enabling the immobilization of genetically engineered cells in a compact, self-sustaining, remotely addressable sensor platform. We used evaporation induced self-assembly (EISA) to immobilize cells within periodic silica nanostructures, characterized by unimodal pore sizes and pore connectivity, that can be patterned using ink-jet printing or photo patterning. We constructed cell lines for the expression of fluorescent proteins and induced reporter protein expression in immobilized cells. We investigated the role of the abiotic/biotic interface during cell-mediated self-assembly of synthetic materials.

• Research Organization: Sandia National Laboratories
• Sponsoring Organization: USDOE
• DOE Contract Number: AC04-94AL85000
• OSTI ID: 918382
• Report Number(s): SAND2003-4075
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
EVAPORATION
IMMOBILIZED CELLS
INSECTS
NANOSTRUCTURES
PROTEINS
SILICA
SYNTHETIC MATERIALS