Ampicillin Trihydrate from Synchrotron Powder Diffraction Data

Journal Article · Sat Dec 31 23:00:00 EST 2005 · Acta Cryst. E

DOI:https://doi.org/10.1107/S1600536806001371· OSTI ID:913997

Burley, J; van de Streek, J; Stephens, P

The crystal structure of ampicillin trihydrate {l_brace}systematic name: 6-[D(-)-{alpha}-aminophenylacetamido]penicillanic acid trihydrate{r_brace}, C{sub 16}H{sub 19}N{sub 3}O{sub 4}S{center_dot}3H{sub 2}O, a broad-spectrum {beta}-lactam antibiotic of the aminopenicillin type, has been determined from synchrotron X-ray powder diffraction data. The three water molecules form an infinite hydrogen-bonded chain through the crystal structure, with hydrogen bonds to the NH{sub 3}{sup +}, COO{sup -}, C{double_bond}O and NH groups of the ampicillin molecules.

• Research Organization: Brookhaven National Laboratory (BNL) National Synchrotron Light Source
• Sponsoring Organization: Doe - Office Of Science
• DOE Contract Number: AC02-98CH10886
• OSTI ID: 913997
• Report Number(s): BNL--78565-2007-JA
• Journal Information: Acta Cryst. E, Journal Name: Acta Cryst. E Vol. 62
• Country of Publication: United States
• Language: English

Related Subjects

08 HYDROGEN
36 MATERIALS SCIENCE
43 PARTICLE ACCELERATORS
ANTIBIOTICS
CHAINS
CRYSTAL STRUCTURE
DIFFRACTION
HYDROGEN
NSLS
SYNCHROTRONS
WATER
national synchrotron light source