No allelic association between Parkinson`s disease and dopamine D2, D3, and D4 receptor gene polymorphisms
- Teikyo Univ. School of Medicine, Tokyo (Japan); and others
Parkinson`s disease is thought to be caused by a combination of unknown environmental, genetic, and degenerative factors. Evidence from necropsy brain samples and pharmacokinetics suggests involvement of dopamine receptors in the pathogenesis or pathophysiology of Parkinson`s disease. Genetic association studies between Parkinson`s disease and dopamine D2, D3 and D4 receptor gene polymorphisms were conducted. The polymorphism was examined in 71 patients with Parkinson`s disease and 90 controls. There were no significant differences between two groups in allele frequencies at the D2, D3, and D4 dopamine receptor loci. Our findings do not support the hypothesis that susceptibility to Parkinson`s disease is associated with the dopamine receptor polymorphisms examined. 35 refs., 2 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 91113
- Journal Information:
- American Journal of Medical Genetics, Vol. 54, Issue 4; Other Information: PBD: 15 Dec 1994
- Country of Publication:
- United States
- Language:
- English
Similar Records
Linkage disequilibrium between an allele at the dopamine D4 receptor locus and Tourette syndrome, by the transmission-disequilibrium test
No evidence of association between structural polymorphism at the dopamine D3 receptor locus and alcoholism in the Japanese