Velo-cardio-facial syndrome and psychotic disorders: Implications for psychiatric genetics
- Univ. of Toronto, Ontario (Canada)
Psychiatric disorders have been reported in over 10% of patients with velo-cardio-facial syndrome (VCFS) in long-term follow-up. To further explore the behavioral and psychiatric findings associated with VCFS in adulthood, detailed clinical histories of two patients - one with VCFS who developed a psychotic illness, and one with schizophrenia who was found to have dysmorphological features associated with VCFS - are described in the current report. The observed overlap of physical and psychiatric symptoms in these two patients suggests that VCFS and psychotic disorders may share a pathogenetic mechanism. This could be consistent with a contiguous gene model for VCFS and psychosis, suggesting chromosome 22q11 as a possible candidate region for genetic studies of schizophrenia. 26 refs., 2 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 91091
- Journal Information:
- American Journal of Medical Genetics, Vol. 54, Issue 2; Other Information: PBD: 15 Jun 1994
- Country of Publication:
- United States
- Language:
- English
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