Chemically-functionalized microcantilevers for detection of chemical, biological and explosive material

Pinnaduwage, Lal A; Thundat, Thomas G; Brown, Gilbert M; Hawk, John Eric; Boiadjiev, Vassil I

Title: Chemically-functionalized microcantilevers for detection of chemical, biological and explosive material

Patent · Tue Apr 24 00:00:00 EDT 2007

OSTI ID:908980

Pinnaduwage, Lal A ^[1]; Thundat, Thomas G ^[1]; Brown, Gilbert M ^[1]; Hawk, John Eric ^[2]; Boiadjiev, Vassil I ^[1]

Knoxville, TN
Olive Branch, MS

A chemically functionalized cantilever system has a cantilever coated on one side thereof with a reagent or biological species which binds to an analyte. The system is of particular value when the analyte is a toxic chemical biological warfare agent or an explosive.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-00OR22725

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Number(s):: 7,207,206

Application Number:: 11/059,170

OSTI ID:: 908980

Country of Publication:: United States

Language:: English

References (11)

Photochemical Hydrosilylation of 11-Undecenyltriethylammonium Bromide with Hydrogen-Terminated Si Surfaces for the Development of Robust Microcantilever Sensors for Cr(VI) Boiadjiev, V. I.; Brown, G. M.; Pinnaduwage, L. A. Langmuir, Vol. 21, Issue 4 https://doi.org/10.1021/la047852n	journal	February 2005
Polymer brushes via surface-initiated polymerizations Edmondson, Steve; Osborne, Vicky L.; Huck, Wilhelm T. S. Chemical Society Reviews, Vol. 33, Issue 1 https://doi.org/10.1039/b210143m	journal	January 2004
Interactions between dendrimer biocides and bacterial membranes Chen, Chris Zhisheng; Cooper, Stuart L. Biomaterials, Vol. 23, Issue 16 https://doi.org/10.1016/S0142-9612(02)00036-4	journal	August 2002
Molecularly imprinted polymers for biosensor applications Yano, K. TrAC Trends in Analytical Chemistry, Vol. 18, Issue 3 https://doi.org/10.1016/S0165-9936(98)00119-8	journal	March 1999
Sensitive detection of plastic explosives with self-assembled monolayer-coated microcantilevers Pinnaduwage, L. A.; Boiadjiev, V.; Hawk, J. E. Applied Physics Letters, Vol. 83, Issue 7 https://doi.org/10.1063/1.1602156	journal	August 2003
Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics Jayasena, Sumedha D. Clinical Chemistry, Vol. 45, Issue 9 https://doi.org/10.1093/clinchem/45.9.1628	journal	September 1999
New Organic Materials Suitable for Use in Chemical Sensor Arrays Crooks, Richard M.; Ricco, Antonio J. Accounts of Chemical Research, Vol. 31, Issue 5 https://doi.org/10.1021/ar970246h	journal	May 1998
Organometallic Chemistry on Silicon and Germanium Surfaces Buriak, Jillian M. Chemical Reviews, Vol. 102, Issue 5 https://doi.org/10.1021/cr000064s	journal	May 2002
Cross-Reactive Chemical Sensor Arrays Albert, Keith J.; Lewis, Nathan S.; Schauer, Caroline L. Chemical Reviews, Vol. 100, Issue 7 https://doi.org/10.1021/cr980102w	journal	July 2000
Detection of Hexavalent Chromium in Ground Water Using a Single Microcantilever Sensor Pinnaduwage, L. A.; Boiadjiev, V. I.; Brown, G. M. Sensor Letters, Vol. 2, Issue 1 https://doi.org/10.1166/sl.2004.028	journal	March 2004
Nerve Agents Detection Using a Cu ²⁺ / l -Cysteine Bilayer-Coated Microcantilever Yang, Yuming; Ji, Hai-Feng; Thundat, Thomas Journal of the American Chemical Society, Vol. 125, Issue 5 https://doi.org/10.1021/ja028181n	journal	February 2003

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